Reaction time and visual memory in connection to alcohol use in persons with bipolar disorder |
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Author: | Mazumder, Atiqul Haq1; Barnett, Jennifer2; Isometsä, Erkki Tapio3,4; |
Organizations: |
1Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland 2Cambridge Cognition, University of Cambridge, Cambridge CB25 9TU, UK 3Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland
4Department of Psychiatry, University of Helsinki, 00014 Helsinki, Finland
5Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland 6Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland 7Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland 8Mehiläinen, Pohjoinen Hesperiankatu 17 C, 00260 Helsinki, Finland 9Department of Psychiatry, University of Turku, 20014 Turku, Finland 10Department of Psychiatry, Turku University Hospital, 20521 Turku, Finland 11Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland 12Department of Psychiatry, Pirkanmaa Hospital District, 33521 Tampere, Finland 13Social Services and Health Care Sector, City of Helsinki, 00099 Helsinki, Finland 14Department of Clinical Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden 15Center for Psychiatry Research, Stockholm City Council, 11364 Stockholm 16Infotech Oulu, University of Oulu, 90014 Oulu, Finland 17Northern Finland Biobank Borealis, Oulu University Hospital, 90220 Oulu, Finland 18Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, Finland 19Kvantum Institute, University of Oulu, 90014 Oulu, Finland 20Stanley Center for Psychiatric Research, The Broad Institute of MIT (Massachusetts Institute of Technology) and Harvard, Cambridge, MA 02142, USA 21Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA 22Department of Psychiatry, Oulu University Hospital, 90220 Oulu, Finland |
Format: | article |
Version: | published version |
Access: | open |
Online Access: | PDF Full Text (PDF, 3.2 MB) |
Persistent link: | http://urn.fi/urn:nbn:fi-fe2021110153190 |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute,
2021
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Publish Date: | 2021-11-01 |
Description: |
AbstractThe purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with bipolar disorder. Alcohol use was assessed through hazardous drinking and alcohol-related disorder including alcohol use disorder (AUD). Hazardous drinking was screened with the Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) screening tool. Alcohol-related disorder diagnoses were obtained from the national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on A tablet computer: the 5-choice serial reaction time task, or reaction time (RT) test and the Paired Associative Learning (PAL) test. Depressive symptoms were assessed with the Mental Health Inventory with five items (MHI-5). However, no assessment of current manic symptoms was available. Association between RT-test and alcohol use was analyzed with log-linear regression, and eβ with 95% confidence intervals (CI) are reported. PAL first trial memory score was analyzed with linear regression, and β with 95% CI are reported. PAL total errors adjusted was analyzed with logistic regression and odds ratios (OR) with 95% CI are reported. After adjustment of age, education, housing status and depression, hazardous drinking was associated with lower median and less variable RT in females while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores in females. Our findings of positive associations between alcohol use and cognition in persons with bipolar disorder are difficult to explain because of the methodological flaw of not being able to separately assess only participants in euthymic phase. see all
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Series: |
Brain sciences |
ISSN: | 2076-3425 |
ISSN-E: | 2076-3425 |
ISSN-L: | 2076-3425 |
Volume: | 11 |
Issue: | 9 |
Article number: | 1154 |
DOI: | 10.3390/brainsci11091154 |
OADOI: | https://oadoi.org/10.3390/brainsci11091154 |
Type of Publication: |
A1 Journal article – refereed |
Field of Science: |
3112 Neurosciences 3124 Neurology and psychiatry |
Subjects: | |
Funding: |
The work was supported by a grant from the Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA (grant agreement nos. 6045290-5500000710 and 6000009-5500000710). The principal author was supported by the H2020 Marie Skłodowska-Curie Actions co-funding of regional, national, and international programs (COFUND) (grant agreement no. 713606) for his doctoral program (MSC-COFUND, I4FUTURE). The principal author was also supported by the Iso-Mällisen Foundation (Iso-Mällisen Säätiö) through a medical grant of EUR 4000 for the year 2019 (grant no. 0400 584622). |
EU Grant Number: |
(713606) I4FUTURE - Novel Imaging and Characterisation Methods in Bio, Medical, and Environmental Research and Technology Innovations |
Copyright information: |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
https://creativecommons.org/licenses/by/4.0/ |