University of Oulu

Deyan Ivanov, Viktor Dremin, Ekaterina Borisova, Alexander Bykov, Igor Meglinski, Tatiana Novikova, and Razvigor Ossikovski "Symmetric decomposition of Mueller matrices reveals a new parametric space for polarimetric assistance in colon cancer histopathology", Proc. SPIE 11646, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics, 1164614 (5 March 2021); https://doi.org/10.1117/12.2578090

Symmetric decomposition of Mueller matrices reveals a new parametric space for polarimetric assistance in colon cancer histopathology

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Author: Ivanov, Deyan1,2; Dremin, Viktor3,4; Borisova, Ekaterina2;
Organizations: 1LPICM, CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, Palaiseau, France
2Institute of Electronics, Bulgarian Academy of Sciences, Sofia, Bulgaria
3College of Engineering and Physical Sciences, Aston University, Birmingham, UK
4Research & Development Center of Biomedical Photonics, Orel State University, Russia
5Optoelectronics and Measurement Techniques unit, University of Oulu, Finland
6Institute of Clinical Medicine N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021110353384
Language: English
Published: SPIE, 2021
Publish Date: 2021-11-03
Description:

Abstract

Tissue polarimetry could be identified as a complementary optical and non-invasive technique to assist the gold standard histopathology analysis of tissue. In general, polarimetric diagnostics is based on tracing different polarimetric responses (including light depolarization) in tissue zones with structure altered by the benign and pre/cancerous formations. In this manuscript, both healthy and malignant tissue zones of a thick formalin-fixed colon specimen were used for Mueller matrix measurements. Additionally, two more Mueller matrices from Monte Carlo simulation and tissue mimicking phantom were also evaluated, in order to assess polarimetric char- acterization and modeling of turbid media. Symmetric decomposition algorithm of Mueller matrices developed in house was adopted to extract both polarization and depolarization properties, encoded in the Mueller matrix elements. The decomposition products allowed to reveal important information about the internal tissue struc- ture and morphology. The depolarization and polarization parameters were found to follow the particular trends that depend on a choice of parametric space.

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Series: Proceedings of SPIE
ISSN: 0277-786X
ISSN-E: 1996-756X
ISSN-L: 0277-786X
ISBN: 978-1-5106-4128-0
ISBN Print: 978-1-5106-4127-3
Article number: 1164614
DOI: 10.1117/12.2578090
OADOI: https://oadoi.org/10.1117/12.2578090
Host publication: Polarized Light and Optical Angular Momentum for Biomedical Diagnostics
Host publication editor: Ramella-Roman, Jessica C.
Ma, Hui
Novikova, Tatiana
Elson, Daniel S.
Vitkin, Alex I.
Conference: Polarized Light and Optical Angular Momentum for Biomedical Diagnostics
Type of Publication: A4 Article in conference proceedings
Field of Science: 213 Electronic, automation and communications engineering, electronics
217 Medical engineering
3111 Biomedicine
Subjects:
Funding: All authors acknowledge the contribution to Dr. Pengcheng Li to Monte Carlo modeling. Deyan Ivanov acknowledges the PhD fellowship funding by the Doctoral School of Institut Polytechnique de Paris. Dr. Victor Dremin kindly acknowledges personal support from the Russian Science Foundation (projects No. 19-79-00082, experimental data collection). This work received funding from NSF of Bulgaria under project #KP06-N28/11/14.12.18 "Novel bio-optical methods for determination of chemical and conformational reorganization of collagen-based tissue structures in vitro and in vivo"; The ATTRACT project funded by the EC under Grant Agreement 777222; Academy of Finland (grants 314639 and 325097) and INFOTECH strategic funding.
Academy of Finland Grant Number: 314639
325097
Detailed Information: 314639 (Academy of Finland Funding decision)
325097 (Academy of Finland Funding decision)
Copyright information: © (2021) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only. Published here with the kind permission by the Publisher.