University of Oulu

Petri Kursula, Shanks — multidomain molecular scaffolds of the postsynaptic density, Current Opinion in Structural Biology, Volume 54, 2019, Pages 122-128, ISSN 0959-440X, https://doi.org/10.1016/j.sbi.2019.01.007.

Shanks : multidomain molecular scaffolds of the postsynaptic density

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Author: Kursula, Petri1,2
Organizations: 1Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen, Norway
2Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021110353410
Language: English
Published: Elsevier, 2019
Publish Date: 2021-11-03
Description:

Abstract

The postsynaptic density (PSD) is a protein-rich assembly below the postsynaptic membrane, formed of large scaffolding proteins. These proteins carry a combination of protein interaction domains, which may interact with several alternative partners; the structure of the protein assembly can be regulated in an activity-dependent manner. A major scaffolding molecule in the PSD is Shank, a family of three main isoforms with highly similar domain structure. Proteins of the Shank family are targets of mutations in neurological disorders, such as autism and schizophrenia. All the predicted folded domains of Shank have now been crystallized. However, for an understanding of the structure and function of full-length Shank and its complexes in the supramolecular PSD assembly, novel complementary approaches and hybrid techniques must be employed.

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Series: Current opinion in structural biology
ISSN: 0959-440X
ISSN-E: 1879-033X
ISSN-L: 0959-440X
Volume: 54
Pages: 122 - 128
DOI: 10.1016/j.sbi.2019.01.007
OADOI: https://oadoi.org/10.1016/j.sbi.2019.01.007
Type of Publication: A1 Journal article – refereed
Field of Science: 1182 Biochemistry, cell and molecular biology
Subjects:
Funding: This research did not receive any-specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Copyright information: © 2019 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/