University of Oulu

Tarakanchikova, Y., Stelmashchuk, O., Seryogina, E., Piavchenko, G., Zherebtsov, E., Dunaev, A., Popov, A., & Meglinski, I. (2018). Allocation of rhodamine-loaded nanocapsules from blood circulatory system to adjacent tissues assessedin vivoby fluorescence spectroscopy. In Laser Physics Letters (Vol. 15, Issue 10, p. 105601). IOP Publishing.

Allocation of rhodamine-loaded nanocapsules from blood circulatory system to adjacent tissues assessed in vivo by fluorescence spectroscopy

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Author: Tarakanchikova, Yana1,2,3,; Stelmashchuk, Olga4; Seryogina, Evgeniya4;
Organizations: 1Opto-Electronics and Measurement Techniques Research Unit, University of Oulu, Oulu, Finland
2Nanobiotechnology Laboratory, St. Petersburg Academic University, St Petersburg, Russia
3Research Institute of Pediatric Oncology, Hematology and Transplantology named by R.M. Gorbacheva, St Petersburg, Russia
4Orеl State University named after I.S. Turgenev, Orel, Russia
5Centre of Preclinical Research, JSC 'Retinoids', Moscow, Russia
6Aston University, Aston Institute of Photonic Technologies, Birmingham, United Kingdom
7Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Tomsk, Russia
8National Research Nuclear University 'MEPhI', Institute of Engineering Physics for Biomedicine (PhysBio), Moscow, Russia
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 10 MB)
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Language: English
Published: IOP Publishing, 2018
Publish Date: 2021-11-05


Modern fluorescent modalities play an important role in the functional diagnostic of various physiological processes in living tissues. Utilizing the fluorescence spectroscopy approach we observe the circulation of fluorescent-labelled nanocapsules with rhodamine tetramethylrhodamine in a microcirculatory blood system. The measurements were conducted transcutaneously on the surface of healthy Wistar rat thighs in vivo. The administration of the preparation capsule suspension with a rhodamine concentration of 5 mg kg⁻¹ of the animal weight resulted in a two-fold increase of fluorescence intensity relative to the baseline level. The dissemination of nanocapsules in the adjacent tissues via the circulatory system was observed and assessed quantitatively. The approach can be used for the transdermal assessment of rhodamine-loaded capsules in vivo.

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Series: Laser physics letters
ISSN: 1612-2011
ISSN-E: 1612-202X
ISSN-L: 1612-2011
Volume: 15
Issue: 10
Article number: 105601
DOI: 10.1088/1612-202X/aad857
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
114 Physical sciences
Funding: This work was supported by the Russian Foundation on Innovations U.M.N.l.K., the 2017 SPIE Optics and Photonics Education Scholarship, the CIMO Fellowship (TM-15-9729, YT), the EDUFI Fellowship (TM-17-10389, YT), the MEPhI Academic Excellence Project (contract no. 02.a03.21.0005, IM), the Tomsk State University Competitiveness Improvement Programme (IM), and the Academy of Finland (grant no. 311698, IM, grant 290596, AP). EZ kindly acknowledges the funding from the European Union's Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie grant agreement no. 703145. AD and ES kindly acknowledges the funding by the Russian Science Foundation under project No 18-15-00201.
Academy of Finland Grant Number: 311698
Detailed Information: 311698 (Academy of Finland Funding decision)
290596 (Academy of Finland Funding decision)
Copyright information: © 2018 Astro Ltd. This is an author-created, un-copyedited version of an article published in Laser Physics Letters. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at