|
|
Allocation of rhodamine-loaded nanocapsules from blood circulatory system to adjacent tissues assessed in vivo by fluorescence spectroscopy |
|---|---|
| Author: | Tarakanchikova, Yana1,2,3,; Stelmashchuk, Olga4; Seryogina, Evgeniya4; |
| Organizations: |
1Opto-Electronics and Measurement Techniques Research Unit, University of Oulu, Oulu, Finland 2Nanobiotechnology Laboratory, St. Petersburg Academic University, St Petersburg, Russia 3Research Institute of Pediatric Oncology, Hematology and Transplantology named by R.M. Gorbacheva, St Petersburg, Russia
4Orеl State University named after I.S. Turgenev, Orel, Russia
5Centre of Preclinical Research, JSC 'Retinoids', Moscow, Russia 6Aston University, Aston Institute of Photonic Technologies, Birmingham, United Kingdom 7Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Tomsk, Russia 8National Research Nuclear University 'MEPhI', Institute of Engineering Physics for Biomedicine (PhysBio), Moscow, Russia |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 10 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2021110554138 |
| Language: | English |
| Published: |
IOP Publishing,
2018
|
| Publish Date: | 2021-11-05 |
| Description: |
AbstractModern fluorescent modalities play an important role in the functional diagnostic of various physiological processes in living tissues. Utilizing the fluorescence spectroscopy approach we observe the circulation of fluorescent-labelled nanocapsules with rhodamine tetramethylrhodamine in a microcirculatory blood system. The measurements were conducted transcutaneously on the surface of healthy Wistar rat thighs in vivo. The administration of the preparation capsule suspension with a rhodamine concentration of 5 mg kg⁻¹ of the animal weight resulted in a two-fold increase of fluorescence intensity relative to the baseline level. The dissemination of nanocapsules in the adjacent tissues via the circulatory system was observed and assessed quantitatively. The approach can be used for the transdermal assessment of rhodamine-loaded capsules in vivo. see all
|
| Series: |
Laser physics letters |
| ISSN: | 1612-2011 |
| ISSN-E: | 1612-202X |
| ISSN-L: | 1612-2011 |
| Volume: | 15 |
| Issue: | 10 |
| Article number: | 105601 |
| DOI: | 10.1088/1612-202X/aad857 |
| OADOI: | https://oadoi.org/10.1088/1612-202X/aad857 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
217 Medical engineering 114 Physical sciences |
| Subjects: | |
| Funding: |
This work was supported by the Russian Foundation on Innovations U.M.N.l.K., the 2017 SPIE Optics and Photonics Education Scholarship, the CIMO Fellowship (TM-15-9729, YT), the EDUFI Fellowship (TM-17-10389, YT), the MEPhI Academic Excellence Project (contract no. 02.a03.21.0005, IM), the Tomsk State University Competitiveness Improvement Programme (IM), and the Academy of Finland (grant no. 311698, IM, grant 290596, AP). EZ kindly acknowledges the funding from the European Union's Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie grant agreement no. 703145. AD and ES kindly acknowledges the funding by the Russian Science Foundation under project No 18-15-00201. |
| Academy of Finland Grant Number: |
311698 290596 |
| Detailed Information: |
311698 (Academy of Finland Funding decision) 290596 (Academy of Finland Funding decision) |
| Copyright information: |
© 2018 Astro Ltd. This is an author-created, un-copyedited version of an article published in Laser Physics Letters. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1612-202x/aad857. |