University of Oulu

Jukka Pihlman, Costan G. Magnussen, Suvi P. Rovio, Katja Pahkala, Eero Jokinen, Tomi P. Laitinen, Nina Hutri-Kähönen, Päivi Tossavainen, Leena Taittonen, Mika Kähönen, Jorma S.A. Viikari, Olli T. Raitakari, Markus Juonala, Joel Nuotio, Association between Number of Siblings and Cardiovascular Risk Factors in Childhood and in Adulthood: The Cardiovascular Risk in Young Finns Study, The Journal of Pediatrics, Volume 237, 2021, Pages 87-95.e1, ISSN 0022-3476, https://doi.org/10.1016/j.jpeds.2021.05.058

Association between number of siblings and cardiovascular risk factors in childhood and in adulthood : the Cardiovascular Risk in Young Finns Study

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Author: Pihlman, Jukka1,2; Magnussen, Costan G.1,2,3; Rovio, Suvi P.1,2;
Organizations: 1Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
2Center for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland
3Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
4Paavo Nurmi Center, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland
5Department of Paediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
6Department of Clinical Physiology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
7Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
8Department of Pediatrics, PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland
9Vaasa Central Hospital, Vaasa, Finland
10Department of Clinical Physiology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
11Department of Internal Medicine, University of Turku, Turku, Finland
12Division of Medicine, Turku University Hospital, Turku, Finland
13Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
14Heart Center, Turku University Hospital and University of Turku, Turku, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021110854268
Language: English
Published: Springer Nature, 2021
Publish Date: 2021-11-08
Description:

Abstract

Objective: To determine the association of number of siblings on cardiovascular risk factors in childhood and in adulthood.

Study design: In total, 3554 participants (51% female) from the Cardiovascular Risk in Young Finns Study with cardiovascular disease risk factor data at baseline 1980 (age 3-18 years) and 2491 participants with longitudinal risk factor data at the 2011 follow-up. Participants were categorized by number of siblings at baseline (0, 1, or more than 1). Risk factors (body mass index, physical activity, hypertension, dyslipidemia, and overweight, and metabolic syndrome) in childhood and in adulthood were used as outcomes. Analyses were adjusted for age and sex.

Results: In childhood, participants without siblings had higher body mass index (18.2 kg/m², 95% CI 18.0-18.3) than those with 1 sibling (17.9 kg/m², 95% CI 17.8-18.0) or more than 1 sibling (17.8 kg/m², 95% CI 17.7-17.9). Childhood physical activity index was lower among participants without siblings (SD -0.08, 95% CI -0.16-0.00) compared with participants with 1 sibling (SD 0.06, 95%CI 0.01-0.11) or more than 1 sibling (SD -0.02, 95% CI -0.07-0.03). OR for adulthood hypertension was lower among participants with 1 sibling (OR 0.73, 95% CI 0.54-0.98) and more than 1 sibling (OR 0.71, 95% CI 0.52-0.97) compared with participants with no siblings. OR for obesity was lower among participants with 1 sibling (OR 0.72, 95% CI 0.54-0.95) and more than 1 sibling (OR 0.75, 95% CI 0.56-1.01) compared with those with no siblings.

Conclusions: Children without siblings had poorer cardiovascular risk factor levels in childhood and in adulthood. The number of siblings could help identify individuals at increased risk that might benefit from early intervention.

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Series: European journal of pediatrics
ISSN: 0340-6199
ISSN-E: 1432-1076
ISSN-L: 0340-6199
Volume: 237
Pages: 87 - 95.e1
DOI: 10.1016/j.jpeds.2021.05.058
OADOI: https://oadoi.org/10.1016/j.jpeds.2021.05.058
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Subjects:
Copyright information: © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/