University of Oulu

Anna Maria Terho, Sari Pelkonen, Ronja Toikkanen, Sari Koivurova, Jarmo Salo, Sinikka Nuojua-Huttunen, Tytti Pokka, Mika Gissler, Aila Tiitinen, Hannu Martikainen, Childhood growth of term singletons born after frozen compared with fresh embryo transfer, Reproductive BioMedicine Online, Volume 43, Issue 4, 2021, Pages 719-726, ISSN 1472-6483, https://doi.org/10.1016/j.rbmo.2021.08.002

Childhood growth of term singletons born after frozen compared with fresh embryo transfer

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Author: Terho, Anna Maria1,2; Pelkonen, Sari1,2; Toikkanen, Ronja3;
Organizations: 1Department of Obstetrics and Gynaecology, Oulu University Hospital, PL 23, Oulu 90029 OYS, Finland
2Medical Research Center, PEDEGO Research Unit, University of Oulu, Oulu, Finland
3Faculty of Medicine, University of Oulu, PL 5000, Oulun Yliopisto Oulu 90014, Finland
4Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, PL 23, Oulu 90029 OYS, Finland
5Gynova Infertility Clinic, Koulukatu 41, Oulu 90100, Finland
6Information Services Department, THL Finnish Institute for Health and Welfare, PL 30, Helsinki 00271, Finland
7Department of Molecular Medicine and Surgery, Karolinska Institutet and Region Stockholm, Academic Primary Health Care Centre Stockholm, Sweden
8Department of Obstetrics and Gynaecology, Helsinki University Hospital, University of Helsinki, PL 140, Helsinki HUS 00029, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021110854284
Language: English
Published: Elsevier, 2021
Publish Date: 2021-11-08
Description:

Abstract

Research question: Is the growth of term singletons born after frozen embryo transfer (FET) comparable to those born after fresh embryo transfer and natural conception up to 5 years of age?

Design: Observational cohort study in an academic medical centre and municipal child health clinics with repeated measurements carried out by medical professionals. Term singletons born after FET (n = 110) and fresh embryo transfer (n = 181) and their matched natural conception controls (n = 543) born in Oulu, Northern Finland, were included. Mean weights, lengths, heights and head circumferences at the ages of 4, 8 and 18 months and 3 and 5 years were compared. At 3 and 5 years, body mass indices were compared.

Results: Childhood growth did not differ between term singletons born after FET, fresh embryo transfer and natural conception, correcting for exact age at measurement and adjusting for maternal body mass index and paternal height.

Conclusions: Similar growth between children born after FET, fresh embryo transfer and natural conception offers reassurance of the safety and feasibility of the steadily increasing use of embryo cryopreservation in assisted reproduction.

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Series: Reproductive biomedicine online
ISSN: 1472-6483
ISSN-E: 1472-6491
ISSN-L: 1472-6483
Volume: 43
Issue: 4
Pages: 719 - 726
DOI: 10.1016/j.rbmo.2021.08.002
OADOI: https://oadoi.org/10.1016/j.rbmo.2021.08.002
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
ART
FET
Funding: Finnish Government Research funding was obtained for this study; a grant from The Alma and KA Snellman Foundation, Oulu, Finland, was awarded to Anna Maria Terho.
Copyright information: © 2021 The Authors. Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0).
  https://creativecommons.org/licenses/by/4.0/