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Childhood growth of term singletons born after frozen compared with fresh embryo transfer |
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| Author: | Terho, Anna Maria1,2; Pelkonen, Sari1,2; Toikkanen, Ronja3; |
| Organizations: |
1Department of Obstetrics and Gynaecology, Oulu University Hospital, PL 23, Oulu 90029 OYS, Finland 2Medical Research Center, PEDEGO Research Unit, University of Oulu, Oulu, Finland 3Faculty of Medicine, University of Oulu, PL 5000, Oulun Yliopisto Oulu 90014, Finland
4Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, PL 23, Oulu 90029 OYS, Finland
5Gynova Infertility Clinic, Koulukatu 41, Oulu 90100, Finland 6Information Services Department, THL Finnish Institute for Health and Welfare, PL 30, Helsinki 00271, Finland 7Department of Molecular Medicine and Surgery, Karolinska Institutet and Region Stockholm, Academic Primary Health Care Centre Stockholm, Sweden 8Department of Obstetrics and Gynaecology, Helsinki University Hospital, University of Helsinki, PL 140, Helsinki HUS 00029, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2021110854284 |
| Language: | English |
| Published: |
Elsevier,
2021
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| Publish Date: | 2021-11-08 |
| Description: |
AbstractResearch question: Is the growth of term singletons born after frozen embryo transfer (FET) comparable to those born after fresh embryo transfer and natural conception up to 5 years of age? Design: Observational cohort study in an academic medical centre and municipal child health clinics with repeated measurements carried out by medical professionals. Term singletons born after FET (n = 110) and fresh embryo transfer (n = 181) and their matched natural conception controls (n = 543) born in Oulu, Northern Finland, were included. Mean weights, lengths, heights and head circumferences at the ages of 4, 8 and 18 months and 3 and 5 years were compared. At 3 and 5 years, body mass indices were compared. Results: Childhood growth did not differ between term singletons born after FET, fresh embryo transfer and natural conception, correcting for exact age at measurement and adjusting for maternal body mass index and paternal height. Conclusions: Similar growth between children born after FET, fresh embryo transfer and natural conception offers reassurance of the safety and feasibility of the steadily increasing use of embryo cryopreservation in assisted reproduction. see all
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| Series: |
Reproductive biomedicine online |
| ISSN: | 1472-6483 |
| ISSN-E: | 1472-6491 |
| ISSN-L: | 1472-6483 |
| Volume: | 43 |
| Issue: | 4 |
| Pages: | 719 - 726 |
| DOI: | 10.1016/j.rbmo.2021.08.002 |
| OADOI: | https://oadoi.org/10.1016/j.rbmo.2021.08.002 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
Finnish Government Research funding was obtained for this study; a grant from The Alma and KA Snellman Foundation, Oulu, Finland, was awarded to Anna Maria Terho. |
| Copyright information: |
© 2021 The Authors. Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0). |
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https://creativecommons.org/licenses/by/4.0/ |