University of Oulu

Mikko T. Nissinen, Nina Hänninen, Mithilesh Prakash, Janne T.A. Mäkelä, Mikko J. Nissi, Juha Töyräs, Miika T. Nieminen, Rami K. Korhonen, Petri Tanska, Functional and structural properties of human patellar articular cartilage in osteoarthritis, Journal of Biomechanics, Volume 126, 2021, 110634, ISSN 0021-9290, https://doi.org/10.1016/j.jbiomech.2021.110634

Functional and structural properties of human patellar articular cartilage in osteoarthritis

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Author: Nissinen, Mikko T.1,2; Hänninen, Nina1,3; Prakash, Mithilesh4;
Organizations: 1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
2Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
3Research Unit of Medical Imaging, Physics, and Technology, University of Oulu, Oulu, Finland
4A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
5Science Service Center, Kuopio University Hospital, Kuopio, Finland
6School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia
7Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 4 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021111054571
Language: English
Published: Elsevier, 2021
Publish Date: 2021-11-10
Description:

Abstract

Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known. Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA. Thus, our aim was to determine the patellar cartilage FRPE properties followed by associating them with the structure and composition. Osteochondral plugs (n = 14) were harvested from the patellae of six cadavers. Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples. The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples. Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05). We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA. The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.

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Series: Journal of biomechanics
ISSN: 0021-9290
ISSN-E: 1873-2380
ISSN-L: 0021-9290
Volume: 126
Article number: 110634
DOI: 10.1016/j.jbiomech.2021.110634
OADOI: https://oadoi.org/10.1016/j.jbiomech.2021.110634
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: Financial support from Academy of Finland (grants #286526, #324529, #285909, #293970, #297033, and #319440), Instrumentarium Science Foundation sr Finland, Finnish Cultural Foundation (Central Fund grant #191044), Maire Lisko Säätiö, Niilo Helanderin Säätiö, Sigrid Juselius foundation, and the Orion Research Foundation are gratefully acknowledged.
Academy of Finland Grant Number: 297033
Detailed Information: 297033 (Academy of Finland Funding decision)
Copyright information: © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0).
  https://creativecommons.org/licenses/by/4.0/