Functional and structural properties of human patellar articular cartilage in osteoarthritis
Nissinen, Mikko T.; Hänninen, Nina; Prakash, Mithilesh; Mäkelä, Janne T. A.; Nissi, Mikko J.; Töyräs, Juha; Nieminen, Miika T.; Korhonen, Rami K.; Tanska, Petri (2021-07-12)
Mikko T. Nissinen, Nina Hänninen, Mithilesh Prakash, Janne T.A. Mäkelä, Mikko J. Nissi, Juha Töyräs, Miika T. Nieminen, Rami K. Korhonen, Petri Tanska, Functional and structural properties of human patellar articular cartilage in osteoarthritis, Journal of Biomechanics, Volume 126, 2021, 110634, ISSN 0021-9290, https://doi.org/10.1016/j.jbiomech.2021.110634
© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0).
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2021111054571
Tiivistelmä
Abstract
Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known. Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA. Thus, our aim was to determine the patellar cartilage FRPE properties followed by associating them with the structure and composition. Osteochondral plugs (n = 14) were harvested from the patellae of six cadavers. Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples. The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples. Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05). We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA. The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.
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