Phosphate concentrations and modifying factors in healthy children from 12 to 24 months of age
Koljonen, Laura; Enlund-Cerullo, Maria; Hauta-alus, Helena; Holmlund-Suila, Elisa; Valkama, Saara; Rosendahl, Jenni; Andersson, Sture; Pekkinen, Minna; Mäkitie, Outi (2021-07-02)
Laura Koljonen, Maria Enlund-Cerullo, Helena Hauta-alus, Elisa Holmlund-Suila, Saara Valkama, Jenni Rosendahl, Sture Andersson, Minna Pekkinen, Outi Mäkitie, Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age, The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 10, October 2021, Pages 2865–2875, https://doi.org/10.1210/clinem/dgab495
© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2021111254962
Tiivistelmä
Abstract
Context:Phosphate homeostasis and its modifiers in early childhood are inadequately characterized.
Objective: To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age.
Design: This study included 525 healthy infants (53% girls), who participated in a randomized vitamin D intervention trial and received daily vitamin D₃ supplementation of either 10 or 30 μg from age 2 weeks to 24 months. Biochemical parameters were measured at 12 and 24 months. Dietary phosphate intake was determined at 12 months.
Main Outcome Measures: Plasma phosphate concentrations at 12 and 24 months of age.
Results: Mean (SD) phosphate concentration decreased from 12 months (1.9 ± 0.15 mmol/L) to 24 months (1.6 ± 0.17 mmol/L) of age (P < 0.001 for repeated measurements). When adjusted by covariates, such as body size, creatinine, serum 25-hydroxyvitamin D, intact and C-terminal fibroblast growth factor 23, mean plasma phosphate was higher in boys than girls during follow-up (P = 0.019). Phosphate concentrations were similar in the vitamin D intervention groups (P > 0.472 for all). Plasma iron was associated positively with plasma phosphate at both time points (B, 0.006 and 0.005; 95% CI, 0.004-0.009 and 0.002-0.008; P < 0.001 at both time points, respectively). At 24 months of age, the main modifier of phosphate concentration was plasma creatinine (B, 0.007; 95% CI 0.003-0.011, P < 0.001).
Conclusion: Plasma phosphate concentration decreased from age 12 to 24 months. In infants and toddlers, the strongest plasma phosphate modifiers were sex, iron, and creatinine, whereas vitamin D supplementation did not modify phosphate concentrations.
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