Skeletal adverse events in childhood cancer survivors : an Adult Life after Childhood Cancer in Scandinavia cohort study |
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Author: | Oskarsson, Trausti1,2; Duun-Henriksen, Anne Katrine3; Bautz, Andrea3; |
Organizations: |
1Department of Paediatric Oncology, Astrid Lindgren Children's Hospital, Stockholm, Sweden 2Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden 3Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark
4Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden
5Clinical Epidemiology Division, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden 6Department of Epidemiology and Public Health, University College London, London, UK 7Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden 8Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland 9Finnish Institute for Statistical and Epidemiological Cancer Research, Finnish Cancer Registry, Helsinki, Finland 10Dana-Farber Cancer Institute/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA 11Department of Pediatrics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 12The Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland 13Faculty of Medicine, University of Iceland, Reykjavik, Iceland 14Division of Paediatric Oncology and Haematology, Skåne University Hospital, Lund, Sweden 15Department of Clinical Sciences, Lund University, Lund, Sweden 16Department of Paediatrics, Aarhus University Hospital, Aarhus, Denmark 17Department of Clinical Medicine, Faculty of Health, Aarhus University and University Hospital, Aarhus, Denmark |
Format: | article |
Version: | published version |
Access: | open |
Online Access: | PDF Full Text (PDF, 1.4 MB) |
Persistent link: | http://urn.fi/urn:nbn:fi-fe2021111254993 |
Language: | English |
Published: |
John Wiley & Sons,
2021
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Publish Date: | 2021-11-12 |
Description: |
AbstractThe dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer survivors diagnosed before 20 years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127 531 age- and sex-matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first-time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29-1.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0-44.5), osteoporosis, RR 4.53 (3.28-6.27), fractures, RR 1.27 (1.20-1.34), osteochondropathies, RR 1.57 (1.28-1.92) and osteoarthrosis, RR 1.48 (1.28-1.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high-risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors. see all
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Series: |
International journal of cancer |
ISSN: | 0020-7136 |
ISSN-E: | 1097-0215 |
ISSN-L: | 0020-7136 |
Volume: | 149 |
Issue: | 11 |
Pages: | 1863 - 1876 |
DOI: | 10.1002/ijc.33741 |
OADOI: | https://oadoi.org/10.1002/ijc.33741 |
Type of Publication: |
A1 Journal article – refereed |
Field of Science: |
3122 Cancers 3123 Gynaecology and paediatrics |
Subjects: | |
Funding: |
This project was supported by a grant from the Swedish Childhood Cancer Foundation, Barncancerfonden (PR2011-0047). The funding sources had no involvement in the content or preparation of the article. |
Copyright information: |
© 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |