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Lumme, J., Savukoski, S., Suvanto, E., Pesonen, P., Auvinen, J., Sebert, S., Hyppönen, E., Järvelin, M., Puukka, K., Herzig, K., Oura, P., Ojaniemi, M., Niinimäki, M. (2021) Early-onset climacterium is not associated with impaired vitamin D status: a population-based study. Menopause, 28 (8), 899-908. doi:10.1097/GME.0000000000001781

Early-onset climacterium is not associated with impaired vitamin D status : a population-based study

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Author: Lumme, Johanna E.1,2,3; Savukoski, Susanna M.1,2,3; Suvanto, Eila TJ.1,2,3;
Organizations: 1PEDEGO Research Unit, University of Oulu, Oulu, Finland
2Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland
3Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
4Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland
5Centre for Life Course Health Research, University of Oulu, Oulu, Finland
6Oulunkaari Health Center, Ii, Finland
7Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College, London, UK
8Australian Centre for Precision Health, University of South Australia, Cancer Research Institute, Adelaide, Australia
9Unit of Clinical and Health Sciences, University of South Australia, Adelaide, Australia
10South Australian Health and Medical Research Institute, Adelaide, Australia
11Biocenter Oulu, University of Oulu, Oulu, Finland
12Department of Life Sciences, College of Health and Life Sciences, Brunel University London Kingston Lane, Uxbridge, Middlesex, UK
13NordLab Oulu, Oulu University Hospital, Oulu, Finland
14Department of Clinical Chemistry, University of Oulu, Oulu, Finland
15Institute of Biomedicine, University of Oulu, Oulu, Finland
16Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland
17Department of Pediatrics and Adolescence, Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2021111755742
Language: English
Published: Wolters Kluwer, 2021
Publish Date: 2022-08-31
Description:

Abstract

Objective: To investigate vitamin D status in women with the onset of the climacteric phase by age 46 as both early menopause and inadequate vitamin D status may increase the risk of adverse health outcomes.

Methods: A cross-sectional study included 2,544, 46-year-old women from a birth cohort. Women were divided into the following two groups according to their menstrual history and follicle-stimulating hormone (FSH) concentration: 1) climacteric (FSH ≥25 IU/L and amenorrhea ≥4 mo,n = 351) and 2) preclimacteric women (FSH <25 IU/L and having regular/irregular menstrual cycles, n = 2,193). Serum 25-hydroxyvitamin D (25(OH)D) concentrations were compared between the groups. A linear regression model was performed to investigate which factors are associated with 25(OH)D status.

Results: Mean serum 25(OH)D concentrations were higher in climacteric compared with preclimacteric women (68.1 ± 19.8 nmol/L vs 65.2 ± 19.3 nmol/L, P = 0.01). However, in the linear regression model, climacteric status was not associated with 25(OH)D status (multivariable adjusted mean difference 4.5 nmol/L, 95% confidence interval −1.4 to 10.4, P = 0.137). A total of 76 of the climacteric women were using systemic estrogen hormone therapy (HT). In a subanalysis, including only climacteric women, the use of HT was associated with higher 25(OH)D status (multivariable adjusted mean difference 5.9 nmol/L, 95% confidence interval 1.3–10.5, P = 0.013).

Conclusions: The onset of the climacteric phase by age 46 was not associated with inadequate 25(OH)D concentrations, whereas HT use was associated with higher 25(OH)D status in women with early-onset climacterium.

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Series: Menopause
ISSN: 1072-3714
ISSN-E: 1530-0374
ISSN-L: 1072-3714
Volume: 28
Issue: 8
Pages: 899 - 908
DOI: 10.1097/GME.0000000000001781
OADOI: https://oadoi.org/10.1097/GME.0000000000001781
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
25-hydroxyvitamin D
Early menopause
Hormone therapy
Population-based study
Vitamin D
Vitamin D supplementation
Article
Funding: This work was supported by the Northern Ostrobothnia Hospital District, the Oulu University Hospital, the University of Oulu, the Päivikki and Sakari Sohlberg foundation, the Health and Biosciences Doctoral Program HBS-DP (UniOGS, University of Oulu), the Finnish Menopause Society, the Juho Vainio Foundation, and the Finnish Medical Foundation. E.S., P.P., J.A., S.S., M.-R.J., K.P., K.-H.H., P.O., and M.O. received no financial support for the research, authorship, and/or publication of this article. E.H. received funding from the Medical Research Council, UK. J.L. received a grant from the Päivikki and Sakari Sohlberg foundation and from the Health and Biosciences Doctoral Program HBS-DP (UniOGS, University of Oulu). S.M.S. received a research grant from the Finnish Menopause Society, the Juho Vainio Foundation, and the Finnish Medical Foundation. M.N. received a research grant from the University of Oulu.
Copyright information: © 2021 The North American Menopause Society. The final authenticated version is available online at https://doi.org/10.1097/GME.0000000000001781.