Bronchoalveolar lavage differential cell count on prognostic assessment of patients with stable or acute interstitial lung disease : a retrospective real-life study
Salonen, Johanna; Lampela, Henri; Keskitalo, Eerika; Vähänikkilä, Hannu; Purokivi, Minna; Kaarteenaho, Riitta (2020-09-12)
Salonen, J., Lampela, H., Keskitalo, E., Vähänikkilä, H., Purokivi, M., & Kaarteenaho, R. (2020). Bronchoalveolar lavage differential cell count on prognostic assessment of patients with stable or acute interstitial lung disease: A retrospective real-life study. Clinical Immunology, 220, 108594. https://doi.org/10.1016/j.clim.2020.108594
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
https://urn.fi/URN:NBN:fi-fe2021112256365
Tiivistelmä
Abstract
BAL cell differential counts of 133 therapy naive ILD patients and 43 patients during acute exacerbation of ILD (AE-ILD) were retrospectively evaluated.
In the 20 patients who underwent BAL both at baseline and during an AE-ILD, there was an increase in neutrophils but a decrease in macrophages and eosinophils in the BAL obtained during AE-ILD. A detectable number of basophils at the baseline was a novel risk factor for earlier death and the occurrence of AE-ILD. Total BAL cell count >160 × 10⁹/L during AE-ILD was correlated with a more favorable prognosis. BAL cell counts <20% of lymphocytes or > 20% of neutrophils during AE-ILD were associated with shorter survival.
AE-ILD exerted significant changes in BAL cell profiles in individual patients. Several BAL-parameters correlated with survival of ILD patients; of these, baseline basophils and total cell count during AE-ILD were novel prognostic markers.
Kokoelmat
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