University of Oulu

Biancari, F., Mariscalco, G., Yusuff, H. et al. European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria. J Cardiothorac Surg 16, 171 (2021). https://doi.org/10.1186/s13019-021-01536-5

European registry of type A aortic dissection (ERTAAD) : rationale, design and definition criteria

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Author: Biancari, Fausto1,2; Mariscalco, Giovanni3; Yusuff, Hakeem3;
Organizations: 1Heart and Lung Center, Helsinki University Hospital, and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, 00029, Helsinki, Finland
2Research Unit of Surgery, Anesthesia and Critical Care, University of Oulu, Oulu, Finland
3Department of Cardiac Surgery, Glenfield Hospital, University Hospitals of Leicester, Leicester, UK
4Southampton University Hospital, Southampton, UK
5UK Aortic Surgery Group, Wessex Cardiothoracic Centre, Division of Cardiac Surgery, Southampton University Hospital, Southampton, UK
6Division of Cardiac Surgery, University of Verona Medical School, Verona, Italy
7Department of Cardio-Thoracic Surgery, Jean Minjoz University Hospital, Besançon, France
8Service de Chirurgie Thoracique et Cardio-vasculaire, Hôpital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France
9Department of Cardiovascular Surgery, Ziekenhuis Oost-Limburg, Genk, Belgium
10Department of Cardiothoracic Surgery, Münster University Hospital, Münster, Germany
11Department of Cardiovascular Surgery, German Aortic Centre Hamburg, University Heart & Vascular Centre Hamburg, Hamburg, Germany
12Institute of Clinical and Experimental Medicine, Prague, Czech Republic
13Northern General Hospital, Herries Road, Sheffield, UK
14Liverpool Cardiovascular Surgery, Liverpool Heart and Chest Hospital, Faculty of Health and Life Sciences, Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK
15Cardiac Surgery Department, University of Udine, Udine, Italy
16Department of Cardiac Surgery, University of Turin, Turin, Italy
17Leipzig Heart center, Leipzig, Germany
18Cardiovascular and Thoracic Surgery, Saint-Luc’s Hospital, Catholic University of Louvain, Brussels, Belgium
19Department of Cardiac Surgery, University Hospital Antwerp, Edegem, Belgium
20Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium
21Department of Cardiac Surgery, AZ St-Jan, Bruges, Belgium
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021112456826
Language: English
Published: Springer Nature, 2021
Publish Date: 2021-11-24
Description:

Abstract

Background: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient’s conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD.

Methods: Nineteen centers of cardiac surgery from seven European countries have collaborated to create a multicentre observational registry (ERTAAD), which will enroll consecutive patients who underwent surgery for acute TAAD from January 2005 to March 2021. Analysis of the impact of patient’s comorbidities, conditions at referral, surgical strategies and perioperative treatment on the early and late adverse events will be performed. The investigators have developed a classification of the urgency of the procedure based on the severity of preoperative hemodynamic conditions and malperfusion secondary to acute TAAD. The primary clinical outcomes will be in-hospital mortality, late mortality and reoperations on the aorta. Secondary outcomes will be stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit.

Discussion: The analysis of this multicentre registry will allow conclusive results on the prognostic importance of critical preoperative conditions and the value of different treatment strategies to reduce the risk of early adverse events after surgery for acute TAAD. This registry is expected to provide insights into the long-term durability of different strategies of surgical repair for TAAD.

Trial registration: ClinicalTrials.gov Identifier: NCT04831073.

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Series: Journal of cardiothoracic surgery
ISSN: 1749-8090
ISSN-E: 1749-8090
ISSN-L: 1749-8090
Volume: 16
Issue: 1
Article number: 171
DOI: 10.1186/s13019-021-01536-5
OADOI: https://oadoi.org/10.1186/s13019-021-01536-5
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
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