University of Oulu

Rantakallio, J., Nevalainen, J., West, S., Ollila, M., Puukka, K., Bloigu, A., Järvelin, M., Tapanainen, J., Franks, S., Dunkel, L., Piltonen, T., Vääräsmäki, M., Morin-Papunen, L. (2021) Association of Self-Reported Polycystic Ovary Syndrome, Obesity, and Weight Gain From Adolescence to Adulthood With Hypertensive Disorders of Pregnancy. Hypertension 77(3), 1010-1019.

Association of self-reported polycystic ovary syndrome, obesity, and weight gain from adolescence to adulthood with hypertensive disorders of pregnancy : a community-based approach

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Author: Rantakallio, Juhani S.S.1; Nevalainen, Jaana E.1; West, Sammeli I.1;
Organizations: 1Department of Obstetrics and Gynecology, University of Oulu and Oulu University Hospital, Medical Research Center, PEDEGO Research Unit, Oulu, Finland
2NordLab Oulu, Department of Clinical Chemistry, Oulu University Hospital, University of Oulu and Medical Research Center, Oulu, Finland
3MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK
4Center for Life Course Health Research, Faculty of Medicine, University of Oulu, PO Box 8000, 90014, Finland
5Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
6Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
7Centre for Endocrinology, William Harvey Research Institute, Barts & the London Medical School, London, UK
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 1.3 MB)
Persistent link:
Language: English
Published: Wolters Kluwer, 2021
Publish Date: 2021-11-25


The purpose of this prospective, population-based cohort study was to evaluate the roles of polycystic ovary syndrome (PCOS), obesity, weight gain, and hyperandrogenemia in the development of hypertensive disorders of pregnancy (HDP) through fertile age both in PCOS and in non-PCOS women. The study population—NFBC1966 (Northern Finland Birth Cohort 1966)—allowed a long-term follow-up of women from age 14 until 46 years who developed HDP (n=408) or did not (n=3373). HDP diagnosis was confirmed by combining hospital discharge records, data from Finnish Medical Birth Registers, and the questionnaire data at age 46. Women with self-reported PCOS (srPCOS; n=279), defined by both oligo-amenorrhea and hirsutism at age 31 or with PCOS diagnosis by age 46, were compared with women without reported PCOS (n=1577). Women with srPCOS had an increased HDP risk (odds ratio, 1.56 [95% CI, 1.03–2.37]), but the association disappeared after adjustment for body mass index. In women with srPCOS and HDP, body mass index increased from age 14 to 46 significantly more than in srPCOS women without HDP (median [interquartile range], 9.82 [6.23–14.6] and 7.21 [4.16–10.5] kg/m², respectively; P<0.001). Also, in non-PCOS women, the increase was higher in women with (7.54 [5.32–11.62] kg/m²; P<0.001) than without HDP (6.33 [3.90–9.33] kg/m²; P<0.001). Increase in waist circumference between ages 31 and 46 years was associated with HDP but not with PCOS. Hyperandrogenemia at 31 or 46 years did not associate with HDP (1.44 [0.98–2.11]). In conclusion, obesity, especially abdominal obesity, and weight gain from adolescence to age 46, but not srPCOS or hyperandrogenemia, were associated with an increased risk of HDP.

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Series: Hypertension
ISSN: 0194-911X
ISSN-E: 1524-4563
ISSN-L: 0194-911X
Volume: 77
Issue: 3
Pages: 1010 - 1019
DOI: 10.1161/HYPERTENSIONAHA.120.15702
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Funding: NFBC1966 (Northern Finland Birth Cohort 1966) has received core funding from the Academy of Finland (project grants 104781, 120315, 129269, 1114194, 24300796, 85547, 285547 [EGEA]), University of Oulu (grant no. 65354 and no 24000692), University Hospital Oulu, Finland (75617, 2/97, 8/97, 24301140), Ministry of Health and Social Affairs (Grant No. 23/251/97, 160/97, 190/97), National Institute for Health and Welfare, Helsinki (Grant No. 54121), Regional Institute of Occupational Health, Oulu, Finland (Grant No. 50621, 54231), European Regional Development Fund (Grant No. 539/2010 A31592) also funded by EU-H2020 LifeCycle Action (grant no. 733206), and the Medical Research Council, United Kingdom (grants no. MR/M013138/1, MRC/BBSRC MR/S03658X/1 [JPI HDHL]).
EU Grant Number: (733206) LIFECYCLE - Early-life stressors and LifeCycle health
Academy of Finland Grant Number: 129269
Detailed Information: 129269 (Academy of Finland Funding decision)
285547 (Academy of Finland Funding decision)
285547 (Academy of Finland Funding decision)
Dataset Reference: The Data Supplement is available with this article at
Copyright information: © 2021 American Heart Association, Inc. The final authenticated version is available online at