University of Oulu

Isohanni, Matti; Jääskeläinen, Erika; Koponen, Hannu; Miller, Brian J.; Leinonen, Esa; Talaslahti, Tiina (2020) Antipsychotics in late-life schizophrenia - a narrative review. Psychiatria Fennica 51, 16-27,

Antipsychotics in late-life schizophrenia : a narrative review

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Author: Isohanni, Matti1; Jääskeläinen, Erika1,2,3; Koponen, Hannu4;
Organizations: 1Center for Life Course Health Research, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland
2Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
3Department of Psychiatry, Oulu University Hospital, Oulu, Finland
4Helsinki University and Helsinki University Hospital, psychiatry, Helsinki, Finland
5Department of Psychiatry, Augusta University, 997 St. Sebastian Way, Augusta, GA 30912
6Faculty of Medicine and Health Technology, Tampere University, Department of Psychiatry, Pitkäniemi Hospital, Tampere University Hospital
7Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.2 MB)
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Language: English
Published: Psykiatrian Tutkimussäätiö, 2020
Publish Date: 2021-11-26


The number of people with late-life schizophrenia is increasing, but few prospective longitudinal studies have analysed antipsychotic use in this group. The aim of this narrative review is to present key points of current knowledge regarding the use of antipsychotics in late-life schizophrenia. In general, antipsychotic medications have had a major impact on symptom relief in schizophrenia. If used with caution, they are relatively safe and effective in older patients. Given the significant somatic comorbidity and excess mortality in late-life schizophrenia, treatment approaches should include a combination of judicious use of antipsychotics with non-pharmacological treatments. Antipsychotics should be used cautiously with the goal of optimizing outcomes with regular monitoring of adverse effects and using lowest effective doses. Cessation of antipsychotic treatment may be possible for some patients.

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Series: Psychiatria Fennica
ISSN: 2489-6152
ISSN-E: 2489-6152
ISSN-L: 2489-6152
Volume: 51
Pages: 16 - 27
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3124 Neurology and psychiatry
Copyright information: © The Author(s) 2020. Psychiatria Fennica uses an open access policy with an open license (Creative Commons) allowing for immediate free access to the work and permitting any user to read, download, copy, distribute, print, search, or link to the full texts of articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose.