Abstract

Digital twins for performance-oriented applications in industrial environments require systematic model maintenance. Model adaptation requires efficient optimization tools and continuous evaluation of measurement quality. The adaptation and model performance evaluation are based on the modeling error, making the adaptation prone also to the measurement errors. In this paper, a framework for combining model adaptation and measurement quality assurance are discussed. Two examples with simulated industrialscale biopharmaceutical penicillin fermentation are presented to illustrate the usability of the framework.