University of Oulu

Sándor-Bajusz, K., Maros, T., Olasz, L., Sándor, G., Hadzsiev, K., Vástyán, A. (2021) The influence of genetic syndromes on the algorithm of cleft lip and palate repair – A retrospective study. Annals of maxillofacial surgery. https://doi.org/10.4103/ams.ams_77_21

The influence of genetic syndromes on the algorithm of cleft lip and palate repair : a retrospective study

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Author: Sándor-Bajusz, Kinga Amália1; Maros, Teodor Barna2; Olasz, Lajos3;
Organizations: 1Departments of Paediatrics University of Pécs, Pécs, Hungary
2Department of Otorhinolaryngology, Ferenc Flór County Hospital, Kistarcsa
3Department of Dentistry, Oral and Maxillofacial Surgery, University of Pécs, Pécs, Hungary
4Department of Oral and Maxillofacial Surgery, Medical Research Centre, University of Oulu, Oulu University Hospital, Oulu, Finland
5Department of Medical Genetics, University of Pécs, Pécs, Hungary
6Paediatric Surgery, Department of Paediatrics, University of Pécs, Pécs, Hungary
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021120859585
Language: English
Published: Wolters Kluwer, 2021
Publish Date: 2021-12-08
Description:

Abstract

Introduction: This study aimed to determine if the treatment algorithm used for nonsyndromic cleft patients required alteration to manage syndromic cleft lip and/or palate patients.

Methods: The records of patients managed by the Pécs Cleft Team between January 1999 and December 2015 were analyzed retrospectively. The sources of the data included clinical and genetic records.

Results: A total of 607 patients were managed by the cleft team during the study. Sixteen patients (2.6%) were noted to be afflicted with a particular identifiable syndrome. Seven different genetic syndromes and one sequence were present in the study. The Pierre Robin sequence occurred most often, comprising 50% of the cohort. The treatment algorithm used in managing nonsyndromic clefts required modification in 13 of the 16 syndromic patients.

Discussion: The presence of a genetic syndrome may notably affect the treatment algorithm in children born with cleft lip and/or palate. The surgical treatment of certain associated anomalies has by necessity, priority over the timing of the reconstruction of the cleft lip and/or cleft palate in syndromic patients.

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Series: Annals of maxillofacial surgery
ISSN: 2231-0746
ISSN-E: 2249-3816
ISSN-L: 2231-0746
Volume: In press
DOI: 10.4103/ams.ams_77_21
OADOI: https://oadoi.org/10.4103/ams.ams_77_21
Type of Publication: A1 Journal article – refereed
Field of Science: 1184 Genetics, developmental biology, physiology
Subjects:
Copyright information: © 2021 The Authors. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
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