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The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network |
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| Author: | Selenius, Jannica S.1,2; Silveira, Patricia P.3,4; Salonen, Minna1,5; |
| Organizations: |
1Folkhälsan Research Center, Finbyntie 136 Karjaa, 10300, Helsinki, Finland 2Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 3Department of Psychiatry, Faculty of Medicine, McGill University, 6875 Boulevard LaSalle, Verdun, QC, H4H1R3, Canada
4Ludmer Centre for Neuroinformatic and Mental Health, Douglas Mental Health University Institute, McGill University, 6875 Boulevard LaSalle, Verdun, QC, H4H1R3, Canada
5Public Health Promotion Unit, The National Institute for Health and Welfare, Helsinki, Finland 6Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland 7National Institute for Health and Welfare, Public Health Promotion Unit, Helsinki, Oulu, Finland 8PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland 9Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 10Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway 11Department of Psychology and Logopedics, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland 12Turku Institute for Advanced Studies, University of Turku, 20014, Turku, Finland 13Department of Obstetrics and Gynecology and Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 14Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.1 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2021121060079 |
| Language: | English |
| Published: |
Springer Nature,
2021
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| Publish Date: | 2021-12-10 |
| Description: |
AbstractTo investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions of the brain. General linear regression models adjusted for age, sex, population stratification, lifestyle factors and body mass index were applied to analyze the data. Both types of depressive symptoms were associated with lower HRQoL (p < 0.0001). HePRS-IR modified the association between the types of depression and mental HRQoL (p for interaction = 0.005). Melancholic type of depressive symptoms was associated with higher mental HRQoL compared to the non-melancholic symptoms among individuals with low hePRS-IR (adjusted mean 4.1, 95% CI 0.7–7.4, p = 0.018). However, no such difference was evident in moderate or high hePRS-IR groups as higher hePRS-IR was associated with lower mental HRQoL (B = − 3.4, 95% CI − 5.6 to − 1.2) in individuals with melancholic type of depressive symptoms. No direct associations were detected between the ePRS-IRs and type of depressive symptoms or HRQoL. Variations in the glucose-insulin metabolism can lower HRQoL in individuals with melancholic depressive symptoms. see all
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| Series: |
Scientific reports |
| ISSN: | 2045-2322 |
| ISSN-E: | 2045-2322 |
| ISSN-L: | 2045-2322 |
| Volume: | 11 |
| Issue: | 1 |
| Article number: | 21588 |
| DOI: | 10.1038/s41598-021-00631-w |
| OADOI: | https://oadoi.org/10.1038/s41598-021-00631-w |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3124 Neurology and psychiatry |
| Subjects: | |
| Funding: |
The authors would like to express their gratitude to the participants in the Helsinki Birth Cohort Study. Also special thanks for the funding of the HBCS to the Finnish Foundation for Cardiovascular Research, Finnish Foundation for Diabetes Research, Juho Vainio Foundation, Academy of Finland, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation, Samfundet Folkhälsan, Finska Läkaresällskapet, Liv och Hälsa, European Commission FP7 (DORIAN) Grant Agreement No. 278603 and EU H2020-PHC-2014-DynaHealth Grant No. 633595 and EU Horizon 2020 Award 733206 LIFECYCLE. Silveira PP is supported by Canadian Institutes of Health Research (CIHR, PJT-166066, PI Silveira PP). |
| EU Grant Number: |
(633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging (733206) LIFECYCLE - Early-life stressors and LifeCycle health |
| Copyright information: |
© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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https://creativecommons.org/licenses/by/4.0/ |