University of Oulu

Selenius, J.S., Silveira, P.P., Salonen, M. et al. The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network. Sci Rep 11, 21588 (2021).

The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network

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Author: Selenius, Jannica S.1,2; Silveira, Patricia P.3,4; Salonen, Minna1,5;
Organizations: 1Folkhälsan Research Center, Finbyntie 136 Karjaa, 10300, Helsinki, Finland
2Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
3Department of Psychiatry, Faculty of Medicine, McGill University, 6875 Boulevard LaSalle, Verdun, QC, H4H1R3, Canada
4Ludmer Centre for Neuroinformatic and Mental Health, Douglas Mental Health University Institute, McGill University, 6875 Boulevard LaSalle, Verdun, QC, H4H1R3, Canada
5Public Health Promotion Unit, The National Institute for Health and Welfare, Helsinki, Finland
6Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
7National Institute for Health and Welfare, Public Health Promotion Unit, Helsinki, Oulu, Finland
8PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
9Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
10Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
11Department of Psychology and Logopedics, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland
12Turku Institute for Advanced Studies, University of Turku, 20014, Turku, Finland
13Department of Obstetrics and Gynecology and Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
14Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
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Language: English
Published: Springer Nature, 2021
Publish Date: 2021-12-10


To investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions of the brain. General linear regression models adjusted for age, sex, population stratification, lifestyle factors and body mass index were applied to analyze the data. Both types of depressive symptoms were associated with lower HRQoL (p < 0.0001). HePRS-IR modified the association between the types of depression and mental HRQoL (p for interaction = 0.005). Melancholic type of depressive symptoms was associated with higher mental HRQoL compared to the non-melancholic symptoms among individuals with low hePRS-IR (adjusted mean 4.1, 95% CI 0.7–7.4, p = 0.018). However, no such difference was evident in moderate or high hePRS-IR groups as higher hePRS-IR was associated with lower mental HRQoL (B = − 3.4, 95% CI − 5.6 to − 1.2) in individuals with melancholic type of depressive symptoms. No direct associations were detected between the ePRS-IRs and type of depressive symptoms or HRQoL. Variations in the glucose-insulin metabolism can lower HRQoL in individuals with melancholic depressive symptoms.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 11
Issue: 1
Article number: 21588
DOI: 10.1038/s41598-021-00631-w
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Funding: The authors would like to express their gratitude to the participants in the Helsinki Birth Cohort Study. Also special thanks for the funding of the HBCS to the Finnish Foundation for Cardiovascular Research, Finnish Foundation for Diabetes Research, Juho Vainio Foundation, Academy of Finland, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation, Samfundet Folkhälsan, Finska Läkaresällskapet, Liv och Hälsa, European Commission FP7 (DORIAN) Grant Agreement No. 278603 and EU H2020-PHC-2014-DynaHealth Grant No. 633595 and EU Horizon 2020 Award 733206 LIFECYCLE. Silveira PP is supported by Canadian Institutes of Health Research (CIHR, PJT-166066, PI Silveira PP).
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
(733206) LIFECYCLE - Early-life stressors and LifeCycle health
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