University of Oulu

Nina Li, Hoomann Mirzakhani, Alexander Kiefer, Julia Koelle, Tytti Vuorinen, Manfred Rauh, Zuqin Yang, Susanne Krammer, Paraskevi Xepapadaki, Anna Lewandowska-Polak, Heikki Lukkarinen, Nan Zhang, Barbara Stanic, Theodor Zimmermann, Marek L. Kowalski, Tuomas Jartti, Claus Bachert, Mübeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto, Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma, iScience, Volume 24, Issue 10, 2021, 103163, ISSN 2589-0042,

Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma

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Author: Li, Nina1; Mirzakhani, Hoomann2; Kiefer, Alexander3;
Organizations: 1Department of Molecular Pneumology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany
2Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Department of Allergy and Pneumology, Children’s Hospital, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany
4Medical Microbiology, Turku University Hospital, Institut of Biomedicine, University of Turku, Turku, Finland
5Department of Allergy, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece
6Department of Rheumatology, Medical University of Lodz, Lodz, Poland
7Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland
8Upper Airways Research Laboratory, Otorhinolaryngology, University of Gent, Gent, Belgium
9Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Herman-Burchard-Strasse 9, Davos, Switzerland
10Department of Immunology and Allergy, Medical University of Lodz, Poland
11PEDEGO Research Unit, Medical Research Center, University of Oulu, Oulu, Finland
12Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland
13Centre for Respiratory Medicine & Allergy, University of Manchester, Manchester, UK
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.8 MB)
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Language: English
Published: Elsevier, 2021
Publish Date: 2021-12-14


RANTES is implicated in allergic asthma and in T cell-dependent clearance of infection. RANTES receptor family comprises CCR1, CCR3, and CCR5, which are G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of RANTES production by epithelial cells. Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. We further translated these studies to a murine model of asthma induced by house dust mite allergen in wild-type RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of RANTES in the resolution of allergen-induced asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased IL-10 production in the lung.

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Series: iScience
ISSN: 2589-0042
ISSN-E: 2589-0042
ISSN-L: 2589-0042
Volume: 24
Issue: 10
Article number: 103163
DOI: 10.1016/j.isci.2021.103163
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
Funding: This work was supported by the European Grant PreDicta Collaborative Project grant 260895 (Post-infectious immune reprogramming and its association with persistence and chronicity of respiratory allergic diseases) awarded to S.F. in Erlangen and in the other European Centers to N.G.P. in Athens, to M.L.K. in Lodz, to T.V. and T.J. in Turku, to C.B. in Gent, and to M.A. in Davos; by the Department of Molecular Pneumology and a IZKF grant in Erlangen. N.L. was supported by a CRC1181 grant awarded to S.F. in Erlangen and by the Molecular Pneumology Department in Erlangen. H.M. was supported by 1 K01HL146977 01A1, 2L30 HL129467-02A1, 5 UH3OD023268 from NHLBI.
Copyright information: © 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (