University of Oulu

Tiina Taka-Eilola (Nèe Riekki), Juha Veijola, Jouko Miettunen, Jari Koskela, Liisa Kantojärvi & Pirjo Mäki (2020) Antisocial and borderline personality disorders in the offspring of antenatally depressed mothers – a follow-up until mid-adulthood in the Northern Finland 1966 birth cohort, Nordic Journal of Psychiatry, 74:2, 138-146, DOI: 10.1080/08039488.2019.1681508

Antisocial and borderline personality disorders in the offspring of antenatally depressed mothers : a follow-up until mid-adulthood in the Northern Finland 1966 birth cohort

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Author: Taka-Eilola (Nèe Riekki), Tiina1,2; Veijola, Juha1,3,4; Miettunen, Jouko4,5;
Organizations: 1Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland
2Basic Health Care District of Kallio, Finland
3Department of Psychiatry, Oulu University Hospital, Oulu, Finland
4Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
5Center for Life Course Health Research, University of Oulu, Oulu, Finland
6Department of Psychiatry, Länsi-Pohja Healthcare District, Kemi, Finland
7Department of Psychiatry, The Middle Ostrobothnia Central Hospital, Soite Mental Health Services, Joint Municipal Authority of Wellbeing in Raahe District, Mental Health Services and Basic Health Care District of Kallio, Finland
8Department of Psychiatry, Kainuu Central Hospital, Kainuu Social and Healthcare District, Kainuu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021121560638
Language: English
Published: Informa, 2020
Publish Date: 2021-12-15
Description:

Abstract

Background: Maternal depression is common during pregnancy, affecting 10–15% of mothers. In previous reports, the offspring of antenatally depressed mothers have had an elevated risk for antisocial, criminal and violent behaviour in adolescence, and for borderline personality features in childhood, but long-term outcomes are unknown.

Aims: To study whether the adult offspring of antenatally depressed mothers have an elevated risk for antisocial (ASPD) or borderline personality disorder (BPD) when followed until mid-adulthood.

Methods: In the general population-based Northern Finland 1966 Birth Cohort, mothers of 12,058 children were asked during mid-gestation if they felt depressed. Of the mothers, 14% reported being depressed. The offspring were followed for 49 years. The diagnoses of in- and outpatient-treated ASPD and BPD in the offspring were detected using the Finnish Care Register for Healthcare. Maternal antenatal smoking, newborn´s low birthweight or short gestational age, father’s social class, and family type at birth were considered as confounding variables. Logistic regression analyses on the potential confounders were performed. Maternal postnatal depression and paternal ASPD information was not available.

Results: In the male offspring of antenatally depressed mothers, the risk for ASPD was elevated (adjusted odds ratio 5.6; 95% confidence interval 1.8–17.8), but not in female offspring. The risk for BPD was not elevated in the offspring of antenatally depressed mothers in this study.

Conclusions: The sons of antenatally depressed mothers had an increased risk for ASPD. Prevention and treatment of antenatal depression might present an opportunity to decrease the risk of antisocial personality in the offspring.

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Series: Nordic journal of psychiatry
ISSN: 0803-9488
ISSN-E: 1502-4725
ISSN-L: 0803-9488
Volume: 74
Issue: 2
Pages: 138 - 146
DOI: 10.1080/08039488.2019.1681508
OADOI: https://oadoi.org/10.1080/08039488.2019.1681508
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Subjects:
Funding: This work was supported by the Academy of Finland; under Grant number #268336 (JM). The NFBC1966 has received financial support from University of Oulu Grant no. 65354, Oulu University Hospital Grant no. 2/97, 8/97, Ministry of Health and Social Affairs Grant no. 23/251/97, 160/97, 190/97, National Institute for Health and Welfare, Helsinki Grant no. 54121, Regional Institute of Occupational Health, Oulu, Finland Grant no. 50621, 54231. NFBC1966 has also received financial support from University of Oulu Grant no. 24000692, Oulu University Hospital Grant no. 24301140 ERDF European Regional Development Fund Grant no. 539/2010 A31592. http://www.oulu.fi/nfbc/node/32454.
Academy of Finland Grant Number: 268336
Detailed Information: 268336 (Academy of Finland Funding decision)
Copyright information: © 2021 Informa UK Limited, trading as Taylor & Francis Group. This is an Accepted Manuscript of an article published by Taylor & Francis in Nordic Journal of Psychiatry on 24 Oct 2019, available online: https://doi.org/10.1080/08039488.2019.1681508.