University of Oulu

Isohanni, M., Jääskeläinen, E., Miller, B.J., Hulkko, A., Tiihonen, J., Möller, H.-J., Hartikainen, S., Huhtaniska, S. and Lieslehto, J. (2021), Medication management of antipsychotic treatment in schizophrenia—A narrative review. Hum Psychopharmacol Clin Exp, 36: e2765. https://doi.org/10.1002/hup.2765

Medication management of antipsychotic treatment in schizophrenia : a narrative review

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Author: Isohanni, Matti1; Jääskeläinen, Erika1; Miller, Brian J.;
Organizations: 1Center for Life Course Health Research, University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2021121560730
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2021-12-15
Description:

Abstract

Background/Objective: The risk-benefit ratio of antipsychotics in schizophrenia depends primarily on their effect on brain chemistry. An important factor influencing the efficacy of prescribed drugs is medication management, which can be defined as an ongoing process to manage and monitor the recommended use of antipsychotics to facilitate their cost-effective, adherent, and acceptable use.

Materials: We reviewed narratively relevant literature that examined the medication management of antipsychotics in schizophrenia based on a search of PubMed, Scopus, Web of Science, PsycARTICLES, and Cochrane in May 2020. We also included controlled interventional studies with a follow-up period of at least 2 years.

Results: Based on the previous literature, there is no unified approach for optimal medication management, but multiple useful strategies are presented for individual patients, prescribers, and organizations.

Conclusions: Systematic medication management may improve the risk-benefit balance of antipsychotics by achieving the lowest effective dose, minimizing adverse effects, and improving adherence. There is a need for well-designed naturalistic studies and clinical trials to optimize management in schizophrenia.

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Series: Human psychopharmacology. Clinical & experimental
ISSN: 0885-6222
ISSN-E: 1099-1077
ISSN-L: 0885-6222
Volume: 36
Issue: 2
Article number: e2765
DOI: 10.1002/hup.2765
OADOI: https://oadoi.org/10.1002/hup.2765
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3124 Neurology and psychiatry
Subjects:
Funding: This study was supported financially by the Finnish Medical Association (Johannes Lieslehto), Yrjö Jahnsson Foundation (Johannes Lieslehto), and Jalmari and Rauha Ahokas Foundation (Johannes Lieslehto).
Copyright information: © 2020 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Isohanni, M., Jääskeläinen, E., Miller, B.J., Hulkko, A., Tiihonen, J., Möller, H.-J., Hartikainen, S., Huhtaniska, S. and Lieslehto, J. (2021), Medication management of antipsychotic treatment in schizophrenia—A narrative review. Hum Psychopharmacol Clin Exp, 36: e2765, which has been published in final form at https://doi.org/10.1002/hup.2765. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.