University of Oulu

Nader, J., López-Vicente, M., Julvez, J., Guxens, M., Cadman, T., Elhakeem, A., Järvelin, M., Rautio, N., Miettunen, J., El Marroun, H., Melchior, M., Heude, B., Charles, M., Yang, T., McEachan, R., Wright, J., Polanska, K., Carson, J., Lin, A., Rauschert, S., Huang, R., Popovic, M., Richiardi, L., Corpeleijn, E., Cardol, M., Mikkola, T., Eriksson, J., Salika, T., Inskip, H., Vinther, J., Strandberg-Larsen, K., Gürlich, K., Grote, V., Koletzko, B., Vafeiadi, M., Sunyer, J., Jaddoe, V., Harris, J. (2021) Cohort description: Measures of early-life behaviour and later psychopathology in the LifeCycle Project - EU Child Cohort Network. Journal of Epidemiology,

Cohort description : measures of early-life behaviour and later psychopathology in the LifeCycle Project — EU Child Cohort Network

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Author: Nader, Johanna L.1; López-Vicente, Mònica2,3; Julvez, Jordi4,2;
Organizations: 1Department of Genetics and Bioinformatics, Division of Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway
2ISGlobal, Instituto de Salud Global de Barcelona, Barcelona, Spain
3Department of Child and Adolescent Psychiatry, University Medical Center Rotterdam, Erasmus MC
4Institut d'Investigació Sanitària Pere Virgili, Hospital Universitari Sant Joan de Reus, 43204 Reus, Spain
5MRC Integrative Epidemiology Unit at University of Bristol, Population Health Sciences, Bristol Medical School, Bristol, UK
6Center for Life Course Health Research, University of Oulu, Oulu, Finland
7Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
8Department of Pediatrics, University Medical Center Rotterdam, Erasmus MC
9The Generation R Study Group, Erasmus MC, Rotterdam, CA, The Netherlands
10Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique, IPLESP, 75012, Paris, France
11Université de Paris, Centre for Research in Epidemiology and Statistics (CRESS), INSERM, INRAE, Paris, France
12Unité mixte Inserm-Ined-EFS Elfe, INED, Paris, France
13Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
14Department of Hygiene and Epidemiology, Medical University of Lodz, Lodz, Poland
15Telethon Kids Institute, University of Western Australia, Australia
16Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO Piemonte, Turin, Italy
17Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
18Folkhälsan Research Center, Helsinki, Finland
19Clinicum, Faculty of Medicine, University of Helsinki, Finland
20Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
21Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
22Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore
23Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
24Medical Research Council Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, UK
25NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK
26Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
27Division of Metabolic and Nutritional Medicine, Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital, LMU, Munich, Germany
28Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece
29Division of Health Data and Digitalization, Center for Fertility and Health and Department of Genetics and Bioinformatics, The Norwegian Institute of Public Health
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.4 MB)
Persistent link:
Language: English
Published: Japan Epidemiological Association, 2021
Publish Date: 2021-12-17


Background: The EU LifeCycle Project was launched in 2017 to combine, harmonise, and analyse data from more than 250,000 participants across Europe and Australia, involving cohorts participating in the EU-funded LifeCycle Project. The purpose of this cohort description is to provide a detailed overview over the major measures within mental health domains that are available in 17 European and Australian cohorts participating in the LifeCycle Project.

Methods: Data on cognitive, behavioural and psychological development has been collected on participants from birth until adulthood through questionnaire and medical data. We developed an inventory of the available data by mapping individual instruments, domain types, and age groups, providing the basis for statistical harmonization across mental health measures.

Results: The mental health data in LifeCycle contain longitudinal and cross-sectional data for ages 0–18+ years, covering domains across a wide range of behavioural and psychopathology indicators and outcomes (including executive function, depression, ADHD and cognition). These data span a unique combination of qualitative data collected through behavioural/cognitive/mental health questionnaires and examination, as well as data from biological samples and indices in the form of brain imaging (MRI, foetal ultrasound) and DNA methylation data. Harmonized variables on a subset of mental health domains have been developed, providing statistical equivalence of measures required for longitudinal meta-analyses across instruments and cohorts.

Conclusions: Mental health data harmonized through the LifeCycle project can be used to study life course trajectories and exposure-outcome models that examine early life risk factors for mental illness and develop predictive markers for later-life disease.

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Series: Journal of epidemiology
ISSN: 0917-5040
ISSN-E: 1349-9092
ISSN-L: 0917-5040
Volume: In press
DOI: 10.2188/jea.JE20210241
Type of Publication: A1 Journal article – refereed
Field of Science: 3141 Health care science
Funding: LifeCycle is a five-year research project that is funded through the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 733206). For more information on individual cohorts’ funding information, refer to Supplementary File 3.
EU Grant Number: (733206) LIFECYCLE - Early-life stressors and LifeCycle health
Copyright information: © 2021 Johanna L. Nader et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.