University of Oulu

Seppälä, M, Jauhiainen, L, Tervo, S, Al-Samadi, A, Rautiainen, M, Salo, T, Lehti, K, Monni, O, Hautaniemi, S, Tynninen, O, Mäkitie, A, Mäkinen, LK, Paavonen, T, Toppila-Salmi, S. The expression and prognostic relevance of CDH3 in tongue squamous cell carcinoma. APMIS. 2021; 129: 717– 728, https://doi.org/10.1111/apm.13176

The expression and prognostic relevance of CDH3 in tongue squamous cell carcinoma

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Author: Seppälä, Miia1; Jauhiainen, Laura1; Tervo, Sanni2;
Organizations: 1Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
2Department of Pathology, University of Tampere, Tampere, Finland
3Translational Immunology Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland
4Department of Otorhinolaryngology, Tampere University Hospital, Tampere, Finland
5Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland
6Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland
7Medical Research Centre, Oulu University Hospital, Oulu, Finland
8Helsinki University Hospital, Helsinki, Finland
9Research Programs Unit, Genome-Scale Biology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
10Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden
11Applied Tumor Genomics Research Program, Faculty of Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
12Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland
13Department of Pathology, University of Helsinki and HUSLAB, Helsinki, Finland
14Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
15Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, HUS Helsinki University Hospital, Helsinki, Finland
16Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
17Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
18Department of Pathology, Fimlab Laboratories and Department of Medicine and Health Technology, Tampere University, Tampere, Finland
19Skin and Allergy Hospital, Helsinki University Hospital, Haartman Institute University of Helsinki, University of Helsinki, Helsinki, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2021122162267
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2022-11-14
Description:

Abstract

P-cadherin (CDH3) is a cell-to-cell adhesion molecule that regulates several cellular homeostatic processes in normal tissues. Lack of CDH3 expression is associated with aggressive behavior in oral squamous cell carcinoma (OSCC). Previous studies have shown that CDH3 is downregulated in high-grade OSCC and its reduced expression is predictive for poorer survival. The aim of this study was to evaluate the expression and prognostic relevance of CDH3 in tongue squamous cell carcinoma (TSCC). A retrospective series of 211 TSCC and 50 lymph node samples were stained immunohistochemically with polyclonal antibody (anti-CDH3). CDH3 expression was assessed semi-quantitatively with light microscopy. Fisher’s exact test was used to compare patient and tumor characteristics, and the correlations were tested by Spearman correlation. Survival curves were drawn by the Kaplan–Meier method and analyzed by the log-rank test. Univariate and multivariate Cox regression was used to estimate the association between CDH3 expression and survival. CDH3 expression did not affect TSCC patient’s disease-specific survival or overall survival. Strong CDH3 expression in the primary tumor predicted poor disease-specific and overall survival in patients with recurrent disease. CDH3 expression in lymph nodes without metastasis was negative in all cases. CDH3 expression was positive in all lymph node metastases with extranodal extension. In contrast to previous report about the prognostic value of CDH3 in OSCC, we were not able to validate the result in TSCC.

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Series: APMIS
ISSN: 0903-4641
ISSN-E: 1600-0463
ISSN-L: 0903-4641
Volume: 129
Issue: 12
Pages: 717 - 728
DOI: 10.1111/apm.13176
OADOI: https://oadoi.org/10.1111/apm.13176
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
Funding: The study was supported by the Competitive Research Funding of Tampere Medical Research Fund & Tampere University Hospital, research grants from the Finnish Medical Foundation, Finnish Association of Otorhinolaryngology and Head & Neck Surgery, Minerva Foundation, Emil Aaltonen Foundation, Väinö and Laina Kivi Foundation, Paulo Foundation, Jane & Aatos Erkko Foundation, The Foundation of Finnish Female Dentist and The Finnish-Norwegian foundation of Medicine. We thank Eini Eskola and Teemu Honkanen for excellent technical assistance.
Copyright information: © 2021 Scandinavian Societies for Medical Microbiology and Pathology. This is the peer reviewed version of the following article: Monni, O, Hautaniemi, S, Tynninen, O, Mäkitie, A, Mäkinen, LK, Paavonen, T, Toppila-Salmi, S. The expression and prognostic relevance of CDH3 in tongue squamous cell carcinoma. APMIS. 2021; 129: 717– 728, which has been published in final form at https://doi.org/10.1111/apm.13176. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.