University of Oulu

Kiiskilä, J., Uotila, P., Haapasaari, K.-M., Kauppila, S., Teppo, H.-R., Kuusisto, M. E. L., Lemma, S., Turpeenniemi-Hujanen, T., Vornanen, M., Eray, M., & Kuittinen, O. (2021). Incidence and clinicopathological features of Follicular T-cell lymphoma in Finland: a population-based immunohistochemical study. Human Pathology, 117, 79–87.

Incidence and clinicopathological features of Follicular T-cell lymphoma in Finland : a population-based immunohistochemical study

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Author: Kiiskilä, Jenni1,2; Uotila, Pyry2,3; Haapasaari, Kirsi-Maria4;
Organizations: 1University of Eastern Finland, Faculty of Health Medicine, Institute of Clinical Medicine, Oncology, 70210 Finland
2Cancer Research and Translational Medicine Research Unit, University of Oulu, 90220 Oulu, Finland
3Department of Oncology and Radiotherapy, Oulu University Hospital, 90029 Oulu, Finland
4Department of Pathology, Oulu University Hospital, 90029 Oulu, Finland
5Medical Research Center Oulu, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland
6Department of Hematology, Oulu University Hospital, 90029 Oulu, Finland
7Department of Pathology, Tampere University Hospital, 33521 Tampere, Finland
8Unit of Hematopathology, Department of Pathology, HUSLAB, Helsinki University Hospital, 00029 Helsinki, Finland
9Department of Oncology and Radiotherapy, Kuopio University Hospital, 70029 Kuopio, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link:
Language: English
Published: Elsevier, 2021
Publish Date: 2022-08-06


Follicular T-cell lymphoma (FTCL) is a rare subtype of mature T-cell lymphoma. It was recently recognized as a separate lymphoma entity in the 2017 revised fourth edition of the World Health Organization classification. The main goals of the present study were to gain better knowledge of the incidence and histopathological and clinical features of FTCL in Finland. In this study, we reviewed all angioimmunoblastic T-cell (AITL) and peripheral T-cell lymphomas, not otherwise specified, from the patient records in three hospital districts in Finland over a 10-year period, to identify FTCL cases and estimate its incidence. Five patients rediagnosed with FTCL and 34 with AITL were analyzed. Hodgkin/Reed-Sternberg (HRS)-like cells were observed in 24 of the 34 AITL cases and four of the five FTCL cases. We found that the main features that differentiated FTCL from AITL were rosetting of T-cells around HRS-like cells, the absence of clear cells, follicular dendritic cell meshwork and T-cell monoclonality. Our estimated incidence of FTCL is 0.20 per 100,000 people in Finland.

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Series: Human pathology
ISSN: 0046-8177
ISSN-E: 1532-8392
ISSN-L: 0046-8177
Volume: 117
Pages: 79 - 87
DOI: 10.1016/j.humpath.2021.07.012
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Funding: This work was supported by a grant from the Finnish Cancer Society and the Väisänen Fund of the Terttu Foundation.
Copyright information: © 2021 Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/