University of Oulu

Khrystyna Zhurakivska, Maija Risteli, Tuula Salo, Davide Sartini, Alessia Salvucci, Giuseppe Troiano, Lorenzo Lo Muzio & Monica Emanuelli (2022) Effects of Fermented Wheat Germ Extract on Oral Cancer Cells: An In Vitro Study, Nutrition and Cancer, 74:6, 2133-2141, DOI: 10.1080/01635581.2021.1976806

Effects of fermented wheat germ extract on oral cancer cells : an in vitro study

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Author: Zhurakivska, Khrystyna1; Risteli, Maija2,3; Salo, Tuula2,3,4,5;
Organizations: 1Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy
2Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
3Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland
4Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
5HUSLAB, Department of Pathology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
6Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
7New York-Marche Structural Biology center, Polytechnic University of Marche, Ancona, Italy
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link:
Language: English
Published: Informa, 2021
Publish Date: 2022-09-13


Oral carcinoma is one of the most aggressive cancers, and despite the advances in the therapy, its mortality is still high. An attention in cancer treatment has focused on natural compounds due to their potential beneficial effects on human health. In this study, the effects of dietary supplement Fermented Wheat Germ Extract (FWGE) on oral tongue squamous cell carcinoma (OTSCC) cells were investigated In Vitro using three cell lines (HSC-3, SAS, SCC-25) with variable aggressiveness. The cell viability was significantly decreased by the treatment with high concentration of FWGE in every cell line. Regarding migration and invasion, HSC-3 and SCC-25 cells were most sensitive to FWGE since their movement was significantly reduced with 5 and 10 mg/ml FWGE, while SAS was inhibited only with 10 mg/ml FWGE. Chemotherapeutic compounds (cisplatin and 5-fluorouracil) significantly reduced all OTSCC cells viability. Importantly, combination of these drugs with 10 mg/ml FWGE significantly decreased the cell viability compared to the treatment with the chemotherapeutics or FWGE alone. Based on these In Vitro experiments, the use of FWGE seems to improve the anticancer effects on OTSCC cells. Further In Vivo and clinical studies should be conducted to verify the positive effects of FWGE for OTSCC patients.

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Series: Nutrition and cancer
ISSN: 0163-5581
ISSN-E: 1532-7914
ISSN-L: 0163-5581
Volume: 74
Issue: 6
Pages: 2133 - 2141
DOI: 10.1080/01635581.2021.1976806
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Funding: The study was funded by authors’ institutions.
Copyright information: © 2021 Informa UK Limited, trading as Taylor & Francis Group. This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 12 Sep 2021, available online: