University of Oulu

Huang, L, Riihioja, I, Tanska, P, et al. Early changes in osteochondral tissues in a rabbit model of post-traumatic osteoarthritis. J Orthop Res. 2021; 39: 2556- 2567. https://doi.org/10.1002/jor.25009

Early changes in osteochondral tissues in a rabbit model of post-traumatic osteoarthritis

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Author: Huang, Lingwei1; Riihioja, Ilari2; Tanska, Petri1;
Organizations: 1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
2Medical Research Center, Bone and Stem Cell Biology Research Group, University of Oulu and Oulu University Hospital, Oulu, Finland
3Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
4Cancer and Translational Medicine Research Unit, Anatomy and Cell Biology, Faculty of Medicine, University of Oulu, Oulu, Finland
5Department of Orthopedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland
6Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
7Human performance laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada
8Biomechanics Laboratory, School of Sports, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 4.4 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe202201031034
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2022-01-03
Description:

Abstract

Concurrent osteoarthritic (OA) manifestations in bone and cartilage are poorly known. To shed light on this issue, this study aims to investigate changes in subchondral bone and articular cartilage at two time points after anterior cruciate ligament transection (ACLT) in a rabbit model. 2 (N = 16) and 8 (N = 10) weeks after ACLT, the subchondral bone structure, cartilage thickness, Osteoarthritis Research Society International (OARSI) score, fixed charged density (FCD), and collagen orientation angle were analyzed. OA related changes were evaluated by comparing the ACLT to the contralateral (C-L) and control knees. Already 2 weeks after ACLT, higher trabecular number in the medial femoral condyle and femoral groove, greater OARSI score in the femoral condyles, and thinner trabeculae in the lateral tibial plateau and femoral groove were observed in ACLT compared to C-L knees. Only minor changes of cartilage collagen orientation in the femoral condyles and femoral groove and smaller FCD in the femoral condyles, medial tibial plateau, femoral groove and patella were observed. 8 weeks post-ACLT, the surgical knees had thinner subchondral plate and trabeculae, and smaller trabecular bone volume fraction in most of the knee locations. OARSI score was greater in the femoral condyle and lateral tibial plateau cartilage. FCD loss was progressive only in the femoral condyle, femoral groove, and patellar cartilage, and minor changes of cartilage collagen orientation angle were present in the femoral condyles, femoral groove, and lateral tibial plateau. We conclude that ACLT induces progressive subchondral bone loss, during which proteoglycan loss occurs followed by their partly recovery, as indicated by FCD results.

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Series: Journal of orthopaedic research
ISSN: 0736-0266
ISSN-E: 1554-527X
ISSN-L: 0736-0266
Volume: 39
Issue: 12
Pages: 2556 - 2567
DOI: 10.1002/jor.25009
OADOI: https://oadoi.org/10.1002/jor.25009
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
3111 Biomedicine
Subjects:
Funding: This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 713645; the European Research Council (ERC) under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement No 336267 and No 281180; Academy of Finland [grant numbers 286526, 303786, 324529]; Saastamoinen Foundation, Päivikki and Sakari Sohlberg Foundation; Finnish Cultural Foundation [grant number 00180796]; Finnish Cultural Foundation: North Savo Regional Fund [grant numbers 65171624, 00191044] and North Ostrobothnia Regional Fund [grant number 60172246]; The Canadian Institutes of Health Research [grant number FDN-143341], The Canada Research Chair Program [grant number 950-200955], and the Killam Foundation [grant number 10001203].
Copyright information: © 2021 The Authors. Journal of Orthopaedic Research ® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  https://creativecommons.org/licenses/by/4.0/