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The gut microbiome in polycystic ovary syndrome and its association with metabolic traits |
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| Author: | Lüll, Kreete1,2; Arffman, Riikka K.3; Sola-Leyva, Alberto4,5; |
| Organizations: |
1Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia 2Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia 3Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Centre, Oulu University Hospital, University of Oulu, Oulu, Finland
4Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain
5Instituto de Investigación Biosanitaria ibs GRANADA, Granada, Spain 6Research Unit of Biomedicine, Medical Research Center, University of Oulu, Oulu University Hospital, Oulu, Finland 7Department of Paediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań, Poland 8Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain 9Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada 10Faculty of Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom 11Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 12Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia 13Competence Centre on Health Technologies, Tartu, Estonia 14Department of Obstetrics and Gynecology, Reproductive Endocrinology and IVF Unit, Oulu, University Hospital, University of Oulu, Oulu, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.8 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe202201041173 |
| Language: | English |
| Published: |
Endocrine society,
2021
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| Publish Date: | 2022-01-04 |
| Description: |
AbstractContext: Despite the gut microbiome being widely studied in metabolic diseases, its role in polycystic ovary syndrome (PCOS) has been scarcely investigated. Objective: Compare the gut microbiome in late fertile age women with and without PCOS and investigate whether changes in the gut microbiome correlate with PCOS-related metabolic parameters. Design: Prospective, case–control study using the Northern Finland Birth Cohort 1966. Setting: General community. Participants: A total of 102 PCOS women and 201 age- and body mass index (BMI)-matched non-PCOS control women. Clinical and biochemical characteristics of the participants were assessed at ages 31 and 46 and analyzed in the context of gut microbiome data at the age of 46. Intervention: (s): None Main outcome measure(s): Bacterial diversity, relative abundance, and correlations with PCOS-related metabolic measures. Results: Bacterial diversity indices did not differ significantly between PCOS and controls (Shannon diversity P = .979, unweighted UniFrac P = .175). Four genera whose balance helps to differentiate between PCOS and non-PCOS were identified. In the whole cohort, the abundance of 2 genera from Clostridiales, Ruminococcaceae UCG-002, and Clostridiales Family XIII AD3011 group, were correlated with several PCOS-related markers. Prediabetic PCOS women had significantly lower alpha diversity (Shannon diversity P = .018) and markedly increased abundance of genus Dorea (false discovery rate = 0.03) compared with women with normal glucose tolerance. Conclusions: PCOS and non-PCOS women at late fertile age with similar BMI do not significantly differ in their gut microbial profiles. However, there are significant microbial changes in PCOS individuals depending on their metabolic health. see all
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| Series: |
Journal of clinical endocrinology & metabolism |
| ISSN: | 0021-972X |
| ISSN-E: | 1945-7197 |
| ISSN-L: | 0021-972X |
| Volume: | 106 |
| Issue: | 3 |
| Pages: | 858 - 871 |
| DOI: | 10.1210/clinem/dgaa848 |
| OADOI: | https://oadoi.org/10.1210/clinem/dgaa848 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
This work was funded by Estonian Research Council grants PUT 1371 (to E.O.), IUT34-16 (to A.S.), Enterprise Estonia grant no. EU48695 (to A.S.), and EMBO Installation grant 3573 (to E.O. and supported K.L., O.A.). E.O. was supported by European Regional Development Fund project no. 15-0012 GENTRANSMED, Estonian Center of Genomics/Roadmap II project no. 16-0125 and Estonian Research Council grant PRG 687. K.L. was supported by The European Regional Development Fund. S.A. was supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and European Regional Development Fund (FEDER): grants RYC-2016-21199 and ENDORE (SAF2017-87526-R); and by FEDER/Junta de Andalucía-Consejería de Economía y Conocimiento: MENDO (B-CTS-500-UGR18). A.S.L. and N.M.M. are funded by the Spanish Ministry of Science, Innovation and Universities: PRE2018-0854409 (A.S.L.) and FPU19/01638 (N.M.M.). T.T.P. and R.K.A. are funded by Finnish Academy and Sigrid Juselius Foundation. NFBC1966 received financial support from University of Oulu grant no. 65354, Oulu University Hospital grant no. 2/97, 8/97, Ministry of Health and Social Affairs grant no. 23/251/97, 160/97, 190/97, National Institute for Health and Welfare, Helsinki grant no. 54121, Regional Institute of Occupational Health, Oulu, Finland grant no. 50621, 54231. NFBC1966 received financial support from University of Oulu grant no. 24000692, Oulu University Hospital grant no. 24301140, ERDF European Regional Development Fund grant no. 539/2010 A31592. S.F. was supported by The Genesis Research Trust UK. |
| Copyright information: |
© The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |