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Mazumder, A.H.; Barnett, J.; Isometsä, E.T.; Lindberg, N.; Torniainen-Holm, M.; Lähteenvuo, M.; Lahdensuo, K.; Kerkelä, M.; Ahola-Olli, A.; Hietala, J.; Kampman, O.; Kieseppä, T.; Jukuri, T.; Häkkinen, K.; Cederlöf, E.; Haaki, W.; Kajanne, R.; Wegelius, A.; Männynsalo, T.; Niemi-Pynttäri, J.; Suokas, K.; Lönnqvist, J.; Tiihonen, J.; Paunio, T.; Vainio, S.J.; Palotie, A.; Niemelä, S.; Suvisaari, J.; Veijola, J. Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder. Brain Sci. 2021, 11, 1422. https://doi.org/10.3390/brainsci11111422

Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective disorder and bipolar disorder

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Author: Mazumder, Atiqul Haq1; Barnett, Jennifer2; Isometsä, Erkki Tapio3;
Organizations: 1Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland
2Cambridge Cognition, University of Cambridge, Cambridge CB25 9TU, UK
3Department of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland
4Mental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland
5Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland
6Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland
7Mehiläinen, Pohjoinen Hesperiankatu 17 C, 00260 Helsinki, Finland
8Department of Psychiatry, University of Turku, 20014 Turku, Finland
9Department of Psychiatry, Turku University Hospital, 20521 Turku, Finland
10Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland
11Department of Psychiatry, Pirkanmaa Hospital District, 33521 Tampere, Finland
12Social Services and Health Care Sector, City of Helsinki, 00099 Helsinki, Finland
13Department of Psychiatry, University of Helsinki, 00014 Helsinki, Finland
14Department of Clinical Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
15Center for Psychiatry Research, Stockholm City Council, 11364 Stockholm, Sweden
16Infotech Oulu, University of Oulu, 90014 Oulu, Finland
17Northern Finland Biobank Borealis, Oulu University Hospital, 90220 Oulu, Finland
18Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, Finland
19Kvantum Institute, University of Oulu, 90014 Oulu, Finland
20Stanley Center for Psychiatric Research, The Broad Institute of MIT (Massachusetts Institute of Technology) and Harvard, Cambridge, MA 02142, USA
21Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA
22Department of Psychiatry, Oulu University Hospital, 90220 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe202201101720
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2021
Publish Date: 2022-01-10
Description:

Abstract

The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.

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Series: Brain sciences
ISSN: 2076-3425
ISSN-E: 2076-3425
ISSN-L: 2076-3425
Volume: 11
Issue: 11
Article number: 1422
DOI: 10.3390/brainsci11111422
OADOI: https://oadoi.org/10.3390/brainsci11111422
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
3112 Neurosciences
Subjects:
Bipolar disorder
Cognition
Hazardous drinking
PGS
Reaction time
Schizoaffective disorder
Schizophrenia
Visual memory
Article
Funding: The work was supported by a grant from the Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA (grant agreement nos. 6045290-5500000710 and 6000009-5500000710). The principal author was supported by the H2020 Marie Skłodowska-Curie Actions co-funding of regional, national, and international programs (COFUND) (grant agreement no. 713606) for his doctoral program (MSC-COFUND, I4FUTURE). The principal author was also supported by the Iso-Mällisen Foundation (Iso-Mällisen Säätiö) through a medical grant of EUR 4000 for the year 2019 (grant no. 0400 584622).
Copyright information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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