University of Oulu

Dolors Pelegí-Sisó, Paula de Prado, Justiina Ronkainen, Mariona Bustamante, Juan R González, methylclock: a Bioconductor package to estimate DNA methylation age, Bioinformatics, Volume 37, Issue 12, 15 June 2021, Pages 1759–1760, https://doi.org/10.1093/bioinformatics/btaa825

methylclock : a Bioconductor package to estimate DNA methylation age

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Author: Pelegí-Sisó, Dolors1; de Prado, Paula1; Ronkainen, Justiina2;
Organizations: 1Barcelona Research Institute for Global Health (ISGlobal), Barcelona, Spain
2Center for Life Course Health Research, University of Oulu, Oulu, Finland
3CIBER in Epidemiology (CIBERESP), Madrid, Spain
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022013111515
Language: English
Published: Oxford University Press, 2021
Publish Date: 2022-01-31
Description:

Abstract

Motivation: Ageing is a biological and psychosocial process related to diseases and mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues. Therefore, epigenetic markers can be used to estimate biological age using DNAm profiling across tissues.

Results: We developed a Bioconductor package that allows computation of several existing DNAm adult/childhood and gestational age clocks. Functions to visualize the DNAm age prediction versus chronological age and the correlation between DNAm clocks are also available as well as other features, such as missing data imputation of cell types’ estimates, that are required for DNAm age clocks.

Availability and implementation: https://github.com/isglobal-brge/methylclock

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Series: Bioinformatics
ISSN: 1367-4803
ISSN-E: 1460-2059
ISSN-L: 1367-4803
Volume: 37
Issue: 12
Pages: 1759 - 1760
DOI: 10.1093/bioinformatics/btaa825
OADOI: https://oadoi.org/10.1093/bioinformatics/btaa825
Type of Publication: A1 Journal article – refereed
Field of Science: 1184 Genetics, developmental biology, physiology
Subjects:
Funding: This research received funding from Ministerio de Ciencia; Innovación y Universidades (MICIU); Agencia Estatal de Investigación (AEI); and Fondo Europeo de Desarrollo Regional, UE [RTI2018-100789-B-I00] also through the ‘Centro de Excelencia Severo Ochoa 2019-2023’ Program [CEX2018-000806-S]; and the Catalan Government through the CERCA Program.
Copyright information: © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model).