University of Oulu

Tegelberg, P., Leppilahti, J.M., Ylöstalo, A. et al. Genome-wide association study of periodontal pocketing in Finnish adults. BMC Oral Health 21, 611 (2021). https://doi.org/10.1186/s12903-021-01964-8

Genome-wide association study of periodontal pocketing in Finnish adults

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Author: Tegelberg, Paula1; Leppilahti, Jussi Miikkael1; Ylöstalo, Atte1,2,3,4;
Organizations: 1Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland
2Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland
3Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
4Biocenter Oulu, University of Oulu, Oulu, Finland
5Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
6National Institute for Health and Welfare, Helsinki, Finland
7Institute of Dentistry, University of Eastern Finland, Kuopio, Finland
8Department of Oral and Maxillofacial Surgery, Kuopio University Hospital, Kuopio, Finland
9Department of Public Health and Welfare, National Institute for Health and Welfare, Helsinki, Finland
10Department of Oral and Maxillofacial Surgery, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022020717871
Language: English
Published: Springer Nature, 2021
Publish Date: 2022-02-07
Description:

Abstract

Background: A genome‐wide association study is an analytical approach that investigates whether genetic variants across the whole genome contribute to disease progression. The aim of this study was to investigate genome-wide associations of periodontal condition measured as deepened periodontal pockets (≥ 4 mm) in Finnish adults.

Methods: This study was based on the data of the national Health 2000 Survey (BRIF8901) in Finland and the Northern Finland Birth Cohort 1966 Study totalling 3,245 individuals. The genotype data were analyzed using the SNPTEST v.2.4.1. The number of teeth with deepened periodontal pockets (≥ 4 mm deep) was employed as a continuous response variable in additive regression analyses performed separately for the two studies and the results were combined in a meta-analysis applying a fixed effects model.

Results: Genome-wide significant associations with the number of teeth with ≥ 4 mm deep pockets were not found at the p-level of < 5 × 10⁻⁸, while in total 17 loci reached the p-level of 5 × 10⁻⁶. Of the top hits, SNP rs4444613 in chromosome 20 showed the strongest association (p = 1.35 × 10⁻⁷).

Conclusion: No statistically significant genome-wide associations with deepened periodontal pockets were found in this study.

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Series: BMC oral health
ISSN: 1472-6831
ISSN-E: 1472-6831
ISSN-L: 1472-6831
Volume: 21
Issue: 1
Article number: 611
DOI: 10.1186/s12903-021-01964-8
OADOI: https://oadoi.org/10.1186/s12903-021-01964-8
Type of Publication: A1 Journal article – refereed
Field of Science: 313 Dentistry
Subjects:
Funding: NFBC 1966 31y follow-up study received financial support from University of Oulu Grant No. 65354, Oulu University Hospital Grant No. 2/97, 8/97, Ministry of Health and Social Affairs Grant no. 23/251/97, 160/97, 190/97, National Institute for Health and Welfare, Helsinki Grant no. 54121, Regional Institute of Occupational Health, Oulu, Finland Grant no. 50621, 54231. NFBC1966 46y follow-up study received financial support from University of Oulu Grant No. 24000692, Oulu University Hospital Grant No. 24301140, ERDF European Regional Development Fund Grant no. 539/2010 A31592. Health 2000 Survey was organized by the National Institute of Health and Welfare (THL) [formerly the National Public Health Institute (KTL) of Finland], (http://www.terveys2000.fi) and partly supported by the Finnish Dental Society Apollonia and the Finnish Dental Association. The first author (PT) was financially supported by the Finnish Dental Society Apollonia with a grant. The work was supported through The Sigrid Juselius Foundation (JK), funds from the Academy of Finland [Grant Numbers 297338 (JK) and 307247 (JK), 326189 (JL)] and Novo Nordisk Foundation [Grant Number NNF17OC0026062] (JK).
Academy of Finland Grant Number: 297338
307247
326189
Detailed Information: 297338 (Academy of Finland Funding decision)
307247 (Academy of Finland Funding decision)
326189 (Academy of Finland Funding decision)
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