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Psychiatric disorders in individuals born very preterm / very low-birth weight : an individual participant data (IPD) meta-analysis |
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| Author: | Anderson, Peter J.1,2; de Miranda, Debora Marques3; Albuquerque, Maicon Rodrigues3; |
| Organizations: |
1Turner Institute for Brain & Mental Health, Monash University, Clayton, Victoria, Australia 2Murdoch Children’s Research Institute, Parkville, Victoria, Australia 3Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
4Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
5Unit for Physiotherapy Services, Trondheim Municipality, Trondheim, Norway 6Department of Physiotherapy, Oslo Metropolitan University, Oslo, Norway 7Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada 8Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada 9Department of Pediatrics, Nationwide Children’s Hospital and The Ohio State University, Columbus, OH, USA 10Department of Psychology and Logopedics, University of Helsinki, Finland 11Finnish Institute for Health and Welfare, Public Health Promotion Unit, Helsinki and Oulu, Finland 12PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu 13Children’s Hospital, Helsinki University Hospital and University of Helsinki, Finland 14UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London, London, UK 15Department of Health Sciences, University of Leicester, Leicester, UK 16School of Health Sciences & Child Wellbeing Institute, University of Canterbury, Christchurch, New Zealand 17Department of Paediatrics, University of Otago, Christchurch, New Zealand 18Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK 19Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom 20Psychology, University of Oulu, Finland 21Department of Psychology and Division of Health Sciences, University of Warwick, UK 22Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia 23Neonatal Services, Royal Women’s Hospital, Parkville, Victoria, Australia 24School of Psychology and Public Health, La Trobe University, Bundoora, Victoria, Australia 25Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.7 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2022021018522 |
| Language: | English |
| Published: |
Elsevier,
2021
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| Publish Date: | 2022-02-10 |
| Description: |
AbstractBackground: Data on psychiatric disorders in survivors born very preterm (VP; <32 weeks) or very low birthweight (VLBW; <1500 g) are sparse. We compared rates of psychiatric diagnoses between VP/VLBW and term-born, normal birthweight (term/NBW) control participants. Methods: This individual participant data (IPD) meta-analysis pooled data from eligible groups in the Adults born Preterm International Collaboration (APIC). Inclusion criteria included: 1) VP/VLBW group (birth weight <1500 g and/or gestational age <32 weeks), 2) normal birth weight/term-born control group (birth weight >2499 g and/or gestational age ≥37 weeks), and 3) structured measure of psychiatric diagnoses using DSM or ICD criteria. Diagnoses of interest were Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Anxiety Disorder, Mood Disorder, Disruptive Behaviour Disorder (DBD), Eating Disorder, and Psychotic Disorder. A systematic search for eligible studies was conducted (PROSPERO Registration Number 47555). Findings: Data were obtained from 10 studies (1385 VP/VLBW participants, 1780 controls), using a range of instruments and approaches to assigning diagnoses. Those born VP/VLBW had ten times higher odds of meeting criteria for ASD (odds ratio [OR] 10·6, 95% confidence interval [CI] 2·50, 44·7), five times higher odds of meeting criteria for ADHD (OR 5·42, 95% CI 3·10, 9·46), twice the odds of meeting criteria for Anxiety Disorder (OR 1·91, 95% CI 1·36, 2·69), and 1·5 times the odds of meeting criteria for Mood Disorder (OR 1·51, 95% CI 1·08, 2·12) than controls. This pattern of findings was consistent within age (<18 years vs. ≥18 years) and sex subgroups. Interpretation: Our data suggests that individuals born VP/VLBW might have higher odds of meeting criteria for certain psychiatric disorders through childhood and into adulthood than term/NBW controls. Further research is needed to corroborate our results and identify factors associated with psychiatric disorders in individuals born VP/VLBW. see all
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| Series: |
EClinicalMedicine |
| ISSN: | 2589-5370 |
| ISSN-E: | 2589-5370 |
| ISSN-L: | 2589-5370 |
| Volume: | 42 |
| Article number: | 101216 |
| DOI: | 10.1016/j.eclinm.2021.101216 |
| OADOI: | https://oadoi.org/10.1016/j.eclinm.2021.101216 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
515 Psychology |
| Subjects: | |
| Funding: |
Support for this project was provided by Australia's National Health & Medical Research Council (Investigator Grant (#1176077 (PJA)), Career Development Fellowship (#1127984 (KL)), Medical Research Future Fund of Australia Career Development Grant (#1141354 (JC)), Project grant (#491246 (LWD)), Centre of Clinical Research Excellence Grant (#546519 (LWD)), Centre of Research Excellence Grant (#1060733 (LWD)); CAPES (Coordenação de Aperfeiçoamento de Pessoal deNível Superior) - International Cooperation General Program (DM, MRA); Canadian Institutes of Health Research Team Grant (#2009H00529 (SS)); National Council for Scientific and Technological Development (CNPq) (DM); Academy of Finland (12848591, 1284859, 1312670, 1324596 (KR)); Academy of Finland (315690 EK)), Foundation for Pediatric Research (EK); Sigrid Juselius Foundation (EK); Signe and Ane Gyllenberg Foundation (EK); European Union's Horizon 2020 research and innovation programme: Project RECAP-Preterm (Grant number: 733280 (DW, KR, MI, KAE, EK, SJ)); European Commission Dynamics of Inequality Across the Life-course: structures and processes (DIAL) (No 724363 for PremLife (KR, DW); Neurologic Foundation of New Zealand (0012/PG; 022/PG (LW)); MRC programme grant (MR/N024869/1 (NM, SJ, DW); Health Research Council of New Zealand (03/196 (LW)); National Institutes of Health, USA (HD050309 (HT)); The Research Council of Norway (MI, KAE); Joint Research Committee between St. Olavs Hospital and Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU) (MI, KAE); Liaison Committee between Central Norway Regional Health Authority and NTNU (MI). |
| Academy of Finland Grant Number: |
315690 |
| Detailed Information: |
315690 (Academy of Finland Funding decision) |
| Copyright information: |
© 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |