University of Oulu

Peter J Anderson, Debora Marques de Miranda, Maicon Rodrigues Albuquerque, Marit Sæbø Indredavik, Kari Anne I. Evensen, Ryan Van Lieshout, Saroj Saigal, H. Gerry Taylor, Katri Raikkonen, Eero Kajantie, Neil Marlow, Samantha Johnson, Lianne J. Woodward, Nicola Austin, Chiara Nosarti, Julia Jaekel, Dieter Wolke, Jeanie LY Cheong, Alice Burnett, Karli Treyvaud, Katherine J Lee, Lex W Doyle, Psychiatric disorders in individuals born very preterm / very low-birth weight: An individual participant data (IPD) meta-analysis, eClinicalMedicine, Volume 42, 2021, 101216, ISSN 2589-5370,

Psychiatric disorders in individuals born very preterm / very low-birth weight : an individual participant data (IPD) meta-analysis

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Author: Anderson, Peter J.1,2; de Miranda, Debora Marques3; Albuquerque, Maicon Rodrigues3;
Organizations: 1Turner Institute for Brain & Mental Health, Monash University, Clayton, Victoria, Australia
2Murdoch Children’s Research Institute, Parkville, Victoria, Australia
3Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
4Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
5Unit for Physiotherapy Services, Trondheim Municipality, Trondheim, Norway
6Department of Physiotherapy, Oslo Metropolitan University, Oslo, Norway
7Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
8Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
9Department of Pediatrics, Nationwide Children’s Hospital and The Ohio State University, Columbus, OH, USA
10Department of Psychology and Logopedics, University of Helsinki, Finland
11Finnish Institute for Health and Welfare, Public Health Promotion Unit, Helsinki and Oulu, Finland
12PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu
13Children’s Hospital, Helsinki University Hospital and University of Helsinki, Finland
14UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London, London, UK
15Department of Health Sciences, University of Leicester, Leicester, UK
16School of Health Sciences & Child Wellbeing Institute, University of Canterbury, Christchurch, New Zealand
17Department of Paediatrics, University of Otago, Christchurch, New Zealand
18Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
19Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom
20Psychology, University of Oulu, Finland
21Department of Psychology and Division of Health Sciences, University of Warwick, UK
22Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia
23Neonatal Services, Royal Women’s Hospital, Parkville, Victoria, Australia
24School of Psychology and Public Health, La Trobe University, Bundoora, Victoria, Australia
25Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
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Language: English
Published: Elsevier, 2021
Publish Date: 2022-02-10


Background: Data on psychiatric disorders in survivors born very preterm (VP; <32 weeks) or very low birthweight (VLBW; <1500 g) are sparse. We compared rates of psychiatric diagnoses between VP/VLBW and term-born, normal birthweight (term/NBW) control participants.

Methods: This individual participant data (IPD) meta-analysis pooled data from eligible groups in the Adults born Preterm International Collaboration (APIC). Inclusion criteria included: 1) VP/VLBW group (birth weight <1500 g and/or gestational age <32 weeks), 2) normal birth weight/term-born control group (birth weight >2499 g and/or gestational age ≥37 weeks), and 3) structured measure of psychiatric diagnoses using DSM or ICD criteria. Diagnoses of interest were Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Anxiety Disorder, Mood Disorder, Disruptive Behaviour Disorder (DBD), Eating Disorder, and Psychotic Disorder. A systematic search for eligible studies was conducted (PROSPERO Registration Number 47555).

Findings: Data were obtained from 10 studies (1385 VP/VLBW participants, 1780 controls), using a range of instruments and approaches to assigning diagnoses. Those born VP/VLBW had ten times higher odds of meeting criteria for ASD (odds ratio [OR] 10·6, 95% confidence interval [CI] 2·50, 44·7), five times higher odds of meeting criteria for ADHD (OR 5·42, 95% CI 3·10, 9·46), twice the odds of meeting criteria for Anxiety Disorder (OR 1·91, 95% CI 1·36, 2·69), and 1·5 times the odds of meeting criteria for Mood Disorder (OR 1·51, 95% CI 1·08, 2·12) than controls. This pattern of findings was consistent within age (<18 years vs. ≥18 years) and sex subgroups.

Interpretation: Our data suggests that individuals born VP/VLBW might have higher odds of meeting criteria for certain psychiatric disorders through childhood and into adulthood than term/NBW controls. Further research is needed to corroborate our results and identify factors associated with psychiatric disorders in individuals born VP/VLBW.

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Series: EClinicalMedicine
ISSN: 2589-5370
ISSN-E: 2589-5370
ISSN-L: 2589-5370
Volume: 42
Article number: 101216
DOI: 10.1016/j.eclinm.2021.101216
Type of Publication: A1 Journal article – refereed
Field of Science: 515 Psychology
Funding: Support for this project was provided by Australia's National Health & Medical Research Council (Investigator Grant (#1176077 (PJA)), Career Development Fellowship (#1127984 (KL)), Medical Research Future Fund of Australia Career Development Grant (#1141354 (JC)), Project grant (#491246 (LWD)), Centre of Clinical Research Excellence Grant (#546519 (LWD)), Centre of Research Excellence Grant (#1060733 (LWD)); CAPES (Coordenação de Aperfeiçoamento de Pessoal deNível Superior) - International Cooperation General Program (DM, MRA); Canadian Institutes of Health Research Team Grant (#2009H00529 (SS)); National Council for Scientific and Technological Development (CNPq) (DM); Academy of Finland (12848591, 1284859, 1312670, 1324596 (KR)); Academy of Finland (315690 EK)), Foundation for Pediatric Research (EK); Sigrid Juselius Foundation (EK); Signe and Ane Gyllenberg Foundation (EK); European Union's Horizon 2020 research and innovation programme: Project RECAP-Preterm (Grant number: 733280 (DW, KR, MI, KAE, EK, SJ)); European Commission Dynamics of Inequality Across the Life-course: structures and processes (DIAL) (No 724363 for PremLife (KR, DW); Neurologic Foundation of New Zealand (0012/PG; 022/PG (LW)); MRC programme grant (MR/N024869/1 (NM, SJ, DW); Health Research Council of New Zealand (03/196 (LW)); National Institutes of Health, USA (HD050309 (HT)); The Research Council of Norway (MI, KAE); Joint Research Committee between St. Olavs Hospital and Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU) (MI, KAE); Liaison Committee between Central Norway Regional Health Authority and NTNU (MI).
Academy of Finland Grant Number: 315690
Detailed Information: 315690 (Academy of Finland Funding decision)
Copyright information: © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (