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Colonic delivery of α-linolenic acid by an advanced nutrient delivery system prolongs glucagon-like peptide-1 secretion and inhibits food intake in mice |
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| Author: | Kamakura, Remi1; Raza, Ghulam Shere1; Mäkilä, Ermei2; |
| Organizations: |
1Faculty of Medicine, University of Oulu, Oulu FI-90220, Finland 2Department of Physics and Astronomy, University of Turku, Turku FI-20014, Finland 3Department of Applied Physics, Faculty of Science and Forestry, University of Eastern Finland, Kuopio FI-70211, Finland
4School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807–8555, Japan
5Department of Pediatric Gastroenterology and Metabolic Diseases, Pediatric Institute, Poznan University of Medical Sciences, Pozna´n 60–572, Poland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.8 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2022021418889 |
| Language: | English |
| Published: |
John Wiley & Sons,
2022
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| Publish Date: | 2022-02-14 |
| Description: |
AbstractScope: Nutrients stimulate the secretion of glucagon-like peptide-1 (GLP-1), an incretin hormone, secreted from enteroendocrine L-cells which decreases food intake. Thus, GLP-1 analogs are approved for the treatment of obesity, yet cost and side effects limit their use. L-cells are mainly localized in the distal ileum and colon, which hinders the utilization of nutrients targeting GLP-1 secretion. This study proposes a controlled delivery system for nutrients, inducing a prolonged endogenous GLP-1 release which results in a decrease food intake. Methods and Results: α-Linolenic acid (αLA) was loaded into thermally hydrocarbonized porous silicon (THCPSi) particles. In vitro characterization and in vivo effects of αLA loaded particles on GLP-1 secretion and food intake were studied in mice. A total of 40.4 ± 3.2% of loaded αLA is released from particles into biorelevant buffer over 24 h, and αLA loaded THCPSi significantly increased in vitro GLP-1 secretion. Single-dose orally given αLA loaded mesoporous particles increased plasma active GLP-1 levels at 3 and 4 h and significantly reduced the area under the curve of 24 h food intake in mice. Conclusions: αLA loaded THCPSi particles could be used to endogenously stimulate sustain gastrointestinal hormone release and reduce food intake. see all
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| Series: |
Molecular nutrition & food research |
| ISSN: | 1613-4125 |
| ISSN-E: | 1613-4133 |
| ISSN-L: | 1613-4125 |
| Volume: | 66 |
| Issue: | 4 |
| Article number: | 2100978 |
| DOI: | 10.1002/mnfr.202100978 |
| OADOI: | https://oadoi.org/10.1002/mnfr.202100978 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3111 Biomedicine |
| Subjects: | |
| Funding: |
The financial support from Jalmari and Rauha Ahokkaan Säätiö, Pohjois-Pohjanmaan Säätiö and Suomen Kulttuurirahasto (RK and GSR) are greatly acknowledged. |
| Copyright information: |
© 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |