University of Oulu

Kamakura, R., Raza, G. S., Mäkilä, E., Riikonen, J., Kovalainen, M., Ueta, Y., Lehto, V.-P., Salonen, J., Herzig, K.-H., Colonic Delivery of α-Linolenic Acid by an Advanced Nutrient Delivery System Prolongs Glucagon-Like Peptide-1 Secretion and Inhibits Food Intake in Mice. Mol. Nutr. Food Res. 2022, 66, 2100978.

Colonic delivery of α-linolenic acid by an advanced nutrient delivery system prolongs glucagon-like peptide-1 secretion and inhibits food intake in mice

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Author: Kamakura, Remi1; Raza, Ghulam Shere1; Mäkilä, Ermei2;
Organizations: 1Faculty of Medicine, University of Oulu, Oulu FI-90220, Finland
2Department of Physics and Astronomy, University of Turku, Turku FI-20014, Finland
3Department of Applied Physics, Faculty of Science and Forestry, University of Eastern Finland, Kuopio FI-70211, Finland
4School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807–8555, Japan
5Department of Pediatric Gastroenterology and Metabolic Diseases, Pediatric Institute, Poznan University of Medical Sciences, Pozna´n 60–572, Poland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.8 MB)
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Language: English
Published: John Wiley & Sons, 2022
Publish Date: 2022-02-14


Scope: Nutrients stimulate the secretion of glucagon-like peptide-1 (GLP-1), an incretin hormone, secreted from enteroendocrine L-cells which decreases food intake. Thus, GLP-1 analogs are approved for the treatment of obesity, yet cost and side effects limit their use. L-cells are mainly localized in the distal ileum and colon, which hinders the utilization of nutrients targeting GLP-1 secretion. This study proposes a controlled delivery system for nutrients, inducing a prolonged endogenous GLP-1 release which results in a decrease food intake.

Methods and Results: α-Linolenic acid (αLA) was loaded into thermally hydrocarbonized porous silicon (THCPSi) particles. In vitro characterization and in vivo effects of αLA loaded particles on GLP-1 secretion and food intake were studied in mice. A total of 40.4 ± 3.2% of loaded αLA is released from particles into biorelevant buffer over 24 h, and αLA loaded THCPSi significantly increased in vitro GLP-1 secretion. Single-dose orally given αLA loaded mesoporous particles increased plasma active GLP-1 levels at 3 and 4 h and significantly reduced the area under the curve of 24 h food intake in mice.

Conclusions: αLA loaded THCPSi particles could be used to endogenously stimulate sustain gastrointestinal hormone release and reduce food intake.

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Series: Molecular nutrition & food research
ISSN: 1613-4125
ISSN-E: 1613-4133
ISSN-L: 1613-4125
Volume: 66
Issue: 4
Article number: 2100978
DOI: 10.1002/mnfr.202100978
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Funding: The financial support from Jalmari and Rauha Ahokkaan Säätiö, Pohjois-Pohjanmaan Säätiö and Suomen Kulttuurirahasto (RK and GSR) are greatly acknowledged.
Copyright information: © 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.