University of Oulu

Hirvonen, M., Sinikumpu, J.-J., Tervonen, O., & Sequeiros, R. B. (2021). Magnetic resonance imaging-guided biopsies in children. Acta Radiologica Open. https://doi.org/10.1177/20584601211053846

Magnetic resonance imaging-guided biopsies in children

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Author: Hirvonen, Mika1; Sinikumpu, Juha-Jaakko2; Tervonen, Osmo1;
Organizations: 1Department of Radiology, Oulu University Hospital, Oulu, Finland
2Department of Paediatric Surgery and Orthopaedics, PEDEGO Research Center, Oulu University Hospital and Oulu University, Oulu, Finland
3Department of Radiology, Turku University Hospital, Turku, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022021819891
Language: English
Published: SAGE Publications, 2021
Publish Date: 2022-02-18
Description:

Abstract

Background:Magnetic resonance imaging (MRI) is used far less as an imaging-guided method for percutaneous biopsies than computed tomography (CT) and ultrasound (US), despite its imaging benefits, particularly in children.

Purpose:To evaluate the feasibility, accuracy and safety of MRI-guided biopsies in paediatric patient population.

Material and Methods: The retrospective study included 57 consecutive paediatric patients (<18 years old). A percutaneous core needle biopsy (PCNB) or trephine biopsy was performed in 53 cases, and an additional fine-needle aspiration biopsy (FNAB) in 26 cases. In 4 cases, a stand-alone FNAB was taken. Biopsies were performed with 0.23 T open and 1.5 T closed MRI scanners. Statistical methods used for confidence intervals and p-values were Wilson score method and chi-square test.

Results:The overall diagnostic accuracy of histologic biopsy was 0.94, with sensitivity 0.82, specificity 1.00, positive predictive value (PPV) 1.00 and negative predictive value (NPV) 0.92. In histological bone biopsies, diagnostic accuracy was 0.96, with sensitivity 0.86, specificity 1.00, PPV 1.00 and NPV 0.94. The FNAB sample diagnosis was associated with the histological diagnosis in 79% of cases. There were no major primary complications and only a few late complications. After biopsy, 83% of the children were ambulatory in 6 h. Anti-inflammatory drugs and paracetamol provided satisfactory pain relief in 96% of the patients after biopsy. Most outpatients (71%) were discharged from hospital either on the same day or 1 day later.

Conclusions:MRI is a technically feasible, accurate and safe guidance tool for performing percutaneous biopsies in children.

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Series: Acta radiologica open
ISSN: 2058-4601
ISSN-E: 2058-4601
ISSN-L: 2058-4601
Volume: 10
Issue: 11
Pages: 1 - 9
Article number: 20584601211053846
DOI: 10.1177/20584601211053846
OADOI: https://oadoi.org/10.1177/20584601211053846
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
Copyright information: © The Author(s) 2021. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
  https://creativecommons.org/licenses/by-nc/4.0/