University of Oulu

Palmu, T, Lehtonen, J, Korhonen, L, et al. Association of different enteroviruses with atopy and allergic diseases in early childhood. Pediatr Allergy Immunol. 2021; 32: 1629– 1636. https://doi.org/10.1111/pai.13577

Association of different enteroviruses with atopy and allergic diseases in early childhood

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Author: Palmu, Tiina1,2; Lehtonen, Jussi1; Korhonen, Laura1,3;
Organizations: 1Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
2Department of Dermatology and Allergology, The Hospital District of South Ostrobothnia, Seinäjoki, Finland
3Department of Dermatology, Tampere University Hospital, Tampere, Finland
4Health and Well-Being Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
5Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland
6Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland
7Center for Child Health Research, Tampere University and Tampere University Hospital, Tampere, Finland
8Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and Tampere University, Seinäjoki/Tampere, Finland
9Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, University of Turku, Turku, Finland
10Department of Pediatrics, Turku University Hospital, Turku, Finland
11Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland
12Department of Pediatrics, University of Oulu and Oulu University Hospital, Oulu, Finland
13Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
14Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
15Department of Pediatrics, Tampere University Hospital, Tampere, Finland
16Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022022220373
Language: English
Published: John Wiley & Sons, 2021
Publish Date: 2022-02-22
Description:

Abstract

Background: Enterovirus (EV) infections, being among the most prevalent viruses worldwide, have been associated with reduced risk of allergic diseases. We sought to determine the association between EVs and allergic sensitization and disease in early childhood.

Methods: The study was carried out in a nested case-control setting within a prospective birth cohort in Finland. We included 138 case children who had specific IgE (s-IgE) sensitization at the age of 5 years and 138 control children without s-IgE sensitization. Allergic disease was recorded at study visits and identified with the ISAAC questionnaire. We screened for the presence of serotype-specific antibodies against 41 EVs at 1–5 years of age and assessed their association with allergic sensitization and disease.

Results: The overall number of EV infections did not differ between s-IgE–sensitized children and non-sensitized control children. However, there was a tendency of case children with an allergic disease having less EV infections than their controls. This observation was statistically significant for species A EVs in case children with atopic dermatitis vs. control children: OR 0.6 (95% CI 0.36–0.99), p = .048.

Conclusion: This study supports the evidence that EV exposure and development of allergic disease are inversely associated. Interestingly, the inverse association was not observed for bare atopic IgE sensitization, but for IgE sensitization coupled with clinical atopic disease. This suggests that environmental factors influencing IgE sensitization may differ from those influencing progression to clinical allergic disease.

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Series: Pediatric allergy and immunology
ISSN: 0905-6157
ISSN-E: 1399-3038
ISSN-L: 0905-6157
Volume: 32
Issue: 8
Pages: 1629 - 1636
DOI: 10.1111/pai.13577
OADOI: https://oadoi.org/10.1111/pai.13577
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Subjects:
Funding: This study was supported by funding from the Finnish Society of Allergology and Immunology, the Ida Montin Foundation, the Finnish Dermatological Society, the Finnish Medical Foundation, the Tampere Tuberculosis Foundation, the Päivikki and Sakari Sohlberg Foundation, the Academy of Finland (Prevaller Consortium), the Juho Vainio Foundation, the Yrjö Jahnsson Foundation, the Competitive Research Funding of the Tampere University Hospital (Grant Nos. 9L035, 9M029, 9P017, 9P057, 9R012, 9R055, 9S015, 9S074, 9T072, 9U016, 9U065, and 9V012), and the Medical Research Funds of Turku and Oulu University Hospitals.
Copyright information: © 2021 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
  https://creativecommons.org/licenses/by-nc/4.0/