University of Oulu

Marcelo Müller-Santos, Janne J Koskimäki, Luis Paulo Silveira Alves, Emanuel Maltempi de Souza, Dieter Jendrossek, Anna Maria Pirttilä, The protective role of PHB and its degradation products against stress situations in bacteria, FEMS Microbiology Reviews, Volume 45, Issue 3, May 2021, fuaa058,

The protective role of PHB and its degradation products against stress situations in bacteria

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Author: Müller-Santos, Marcelo1; Koskimäki, Janne J.2; Silveira Alves, Luis Paulo1;
Organizations: 1Department of Biochemistry and Molecular Biology, Federal University of Paraná – UFPR, Setor de Ciências Biológicas, Centro Politécnico, Jardim da Américas, CEP: 81531-990, Caixa Postal: 190-46, Curitiba, Paraná, Brazil
2Ecology and Genetics Research Unit, University of Oulu, Pentti Kaiteran katu 1, P.O. Box 3000, FI-90014 Oulu, Finland
3Institute of Microbiology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: Oxford University Press, 2021
Publish Date: 2022-02-22


Many bacteria produce storage biopolymers that are mobilized under conditions of metabolic adaptation, for example, low nutrient availability and cellular stress. Polyhydroxyalkanoates are often found as carbon storage in Bacteria or Archaea, and of these polyhydroxybutyrate (PHB) is the most frequently occurring PHA type. Bacteria usually produce PHB upon availability of a carbon source and limitation of another essential nutrient. Therefore, it is widely believed that the function of PHB is to serve as a mobilizable carbon repository when bacteria face carbon limitation, supporting their survival. However, recent findings indicate that bacteria switch from PHB synthesis to mobilization under stress conditions such as thermal and oxidative shock. The mobilization products, 3-hydroxybutyrate and its oligomers, show a protective effect against protein aggregation and cellular damage caused by reactive oxygen species and heat shock. Thus, bacteria should have an environmental monitoring mechanism directly connected to the regulation of the PHB metabolism. Here, we review the current knowledge on PHB physiology together with a summary of recent findings on novel functions of PHB in stress resistance. Potential applications of these new functions are also presented.

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Series: FEMS microbiology reviews
ISSN: 0168-6445
ISSN-E: 1574-6976
ISSN-L: 0168-6445
Volume: 45
Issue: 3
Article number: fuaa058
DOI: 10.1093/femsre/fuaa058
Type of Publication: A1 Journal article – refereed
Field of Science: 1183 Plant biology, microbiology, virology
Funding: The work in the laboratory of MMS, LPS and EMS was funded by CNPq (Brazilian National Council for Scientific and Technological Development), project ‘Compreendendo os mecanismos de síntese e degradação de polihidroxibutirato (PHB) e o seu papel no controle redox em bactérias’ process #313710/2018–0. LPS is also supported by CAPES (Coordination of Superior Level Staff Improvement), PNPD process 88882.306029/2018–01.
Copyright information: © The Author(s) 2020. Published by Oxford University Press on behalf of FEMS. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (