University of Oulu

M. T. Barros et al., "Molecular Communications in Viral Infections Research: Modeling, Experimental Data, and Future Directions," in IEEE Transactions on Molecular, Biological and Multi-Scale Communications, vol. 7, no. 3, pp. 121-141, Sept. 2021, doi: 10.1109/TMBMC.2021.3071780

Molecular communications in viral infections research : modeling, experimental data, and future directions

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Author: Barros, Michael Taynnan1,2; Veletić, Mladen3,4; Kanada, Masamitsu5;
Organizations: 1School of Computer Science and Electronic Engineering, University of Essex, Colchester, UK
2CBIG/BioMediTech, Tampere University, Tampere, Finland
3Intervention Centre, Oslo University Hospital, Oslo, Norway
4Department of Electronic Systems, Norwegian University of Science and Technology, Trondheim, Norway
5Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA
6Department of Computer Science and Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA
7Biocenter Oulu, Laboratory of Developmental Biology, Oulu University, Oulu, Finland
8Telecommunications Software and Systems Group, Waterford Institute of Technology, Waterford City, Ireland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 1.6 MB)
Persistent link:
Language: English
Published: Institute of Electrical and Electronics Engineers, 2021
Publish Date: 2022-02-23


Hundreds of millions of people worldwide are affected by viral infections each year, and yet, several of them neither have vaccines nor effective treatment during and post-infection. This challenge has been highlighted by the COVID-19 pandemic, showing how viruses can quickly spread and impact society as a whole. Novel interdisciplinary techniques must emerge to provide forward-looking strategies to combat viral infections, as well as possible future pandemics. In the past decade, an interdisciplinary area involving bioengineering, nanotechnology and information and communication technology (ICT) has been developed, known as Molecular Communications. This new emerging area uses elements of classical communication systems to molecular signalling and communication found inside and outside biological systems, characterizing the signalling processes between cells and viruses. In this paper, we provide an extensive and detailed discussion on how molecular communications can be integrated into the viral infectious diseases research, and how possible treatment and vaccines can be developed considering molecules as information carriers. We provide a literature review on molecular communications models for viral infection (intra-body and extra-body), a deep analysis on their effects on immune response, how experimental can be used by the molecular communications community, as well as open issues and future directions.

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Series: IEEE transactions on molecular, biological, and multi-scale communications
ISSN: 2372-2061
ISSN-E: 2332-7804
ISSN-L: 2372-2061
Volume: 7
Issue: 3
Pages: 121 - 141
DOI: 10.1109/TMBMC.2021.3071780
Type of Publication: A1 Journal article – refereed
Field of Science: 213 Electronic, automation and communications engineering, electronics
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