University of Oulu

Konstari, S., Sääksjärvi, K., Heliövaara, M., Rissanen, H., Knekt, P., Arokoski, J. P. A., & Karppinen, J. (2021). Associations of Metabolic Syndrome and Its Components with the Risk of Incident Knee Osteoarthritis Leading to Hospitalization: A 32-Year Follow-up Study. CARTILAGE, 13(1), 1445S-1456S.

Associations of metabolic syndrome and its components with the risk of incident knee osteoarthritis leading to hospitalization : a 32-year follow-up study

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Author: Konstari, Sanna1,2; Sääksjärvi, Katri3; Heliövaara, Markku3;
Organizations: 1Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Finland
2Center for Life Course Health Research, University of Oulu, Oulu, Finland
3Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland
4Department of Physical and Rehabilitation Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
5Finnish Institute of Occupational Health, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
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Language: English
Published: SAGE Publications, 2021
Publish Date: 2022-02-23


Objectives: To examine whether metabolic syndrome or its individual components predict the risk of incident knee osteoarthritis (OA) in a prospective cohort study during a 32-year follow-up period.

Design: The cohort consisted of 6274 participants of the Mini-Finland Health Survey, who were free from knee OA and insulin-treated diabetes at baseline. Information on the baseline characteristics, including metabolic syndrome components, hypertension, elevated fasting glucose, elevated triglycerides, reduced high-density lipoprotein, and central obesity were collected during a health examination. We drew information on the incidence of clinical knee OA from the national Care Register for Health Care. Of the participants, 459 developed incident knee OA. In our full model, age, gender, body mass index, history of physical workload, smoking history, knee complaint, and previous injury of the knee were entered as potential confounding factors.

Results: Having metabolic syndrome at baseline was not associated with an increased risk of incident knee OA. In the full model, the hazard ratio for incident knee OA for those with metabolic syndrome was 0.76 (95% confidence interval [0.56, 1.01]). The number of metabolic syndrome components or any individual component did not predict an increased risk of knee OA. Of the components, elevated plasma fasting glucose was associated with a reduced risk of incident knee OA (hazard ratio 0.71, 95% confidence interval [0.55, 0.91]).

Conclusions: Our findings do not support the hypothesis that metabolic syndrome or its components increase the risk of incident knee OA. In fact, elevated fasting glucose levels seemed to predict a reduced risk.

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Series: Cartilage
ISSN: 1947-6035
ISSN-E: 1947-6043
ISSN-L: 1947-6035
Volume: 13
Issue: 1
Pages: 1445S - 1456S
DOI: 10.1177/1947603519894731
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Copyright information: © The Author(s) 2019. Article reuse guidelines: The final authenticated version is available online at