University of Oulu

Saramies, J., Koiranen, M., Auvinen, J., Uusitalo, H., Hussi, E., Cederberg, H., Keinänen-Kiukaanniemi, S., & Tuomilehto, J. (2021). 22-year trends in dysglycemia and body mass index: A population-based cohort study in Savitaipale, Finland. Primary Care Diabetes, 15(6), 977–984.

22-year trends in dysglycemia and body mass index : a population-based cohort study in Savitaipale, Finland

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Author: Saramies, Jouko1,2; Koiranen, Markku2; Auvinen, Juha2,3;
Organizations: 1South Karelia Social and Health Care District, Finland
2Center for Life Course Health Research, University of Oulu, Oulu, Finland
3Medical Research Center, Oulu University Hospital, Oulu, Finland
4SILK, Department of Ophthalmology, Faculty of Medicine and Health Technology, Tampere University, PL 100, 33014 Tampere, Finland
5Tays Eye Centre, Tampere University Hospital, Tampere, Finland
6Department of Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland
7Healthcare and Social Services of Selänne, Pyhäjärvi, Finland
8Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
9Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
Format: article
Version: accepted version
Access: embargoed
Persistent link:
Language: English
Published: Elsevier, 2021
Publish Date: 2022-10-11


Aims: We describe a 22-year prospective observational population-based study that determined the prevalence and incidence of type 2 diabetes (T2D) and intermediate hyperglycaemia (IH), obesity, hypertension, and disorders of lipid metabolism in a middle-age population in the Finnish municipality of Savitaipale.

Methods: 1151 people participated in the baseline survey in 1996–1999, following two follow-up examinations, in 2007–2008 and 2018−2019. Follow-up studies comprised clinical measurements, 2-h oral glucose tolerance test and other biochemistry, questionnaires, and registry data.

Results: The prevalence of T2D quadrupled to 27% and the proportion of normoglycemic people decreased from 73% to 44% while IH increased only slightly during the 22-year follow-up. A large proportion of people who died between the surveys were diabetic.

The mean body mass index (BMI) did not, whereas mean waist circumference increased significantly, by 5−6 cm (P = 0.001) during the 22 years. Systolic blood pressure increased by 13−15 mmHg from baseline (P = 0.0001) but diastolic blood pressure did not. The mean plasma levels of total and LDL-cholesterol decreased 10.8% and 8.9% in women (P = 0.001), 21.5% and 22.2% in men (P = 0.001), respectively, while HDL-cholesterol and triglycerides remained stable. The proportion of those achieving targets in the treatment of dyslipidaemia increased significantly (P < 0.001).

Conclusions: In this 22-year prospective follow-up study of in middle-aged Europeans with high participation rates, the progression of dysglycaemia to overt diabetes with aging was rapid, even without a significant change in BMI.

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Series: Primary care diabetes
ISSN: 1751-9918
ISSN-E: 1878-0210
ISSN-L: 1751-9918
Volume: 15
Issue: 6
Pages: 977 - 984
DOI: 10.1016/j.pcd.2021.09.010
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: This work was supported by Savitaipale community and health centre, EVO grants and support by the South Karelia Social and Health Care District, Viipurin tuberkuloosisäätiö, and Elsemay Björn Fund.
Copyright information: © 2021 Primary Care Diabetes Europe. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license