University of Oulu

Antti Mäkitie, Alexander Kamali, Rayan Mroueh, Andrew Lindford, Petri Koivunen, Timo Autio, Patrik Lassus, Martin Halle, Leif Bäck, Björn Palmgren & Lalle Hammarstedt-Nordenvall (2020) A descriptive study highlighting the differences in the treatment protocol for oral tongue cancer in Sweden and Finland, Acta Oto-Laryngologica, 140:2, 188-194, DOI: 10.1080/00016489.2019.1699663

A descriptive study highlighting the differences in the treatment protocol for oral tongue cancer in Sweden and Finland

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Author: Mäkitie, Antti1,2,3; Kamali, Alexander4; Mroueh, Rayan1;
Organizations: 1Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
2Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
3Department of Clinical Science, Intervention and Technology, Department of Oto-Rhino- Laryngology, Head and Neck Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
4Department of Molecular Medicine and Surgery, Department of Reconstructive Plastic Surgery, Karolinska University Hospital, Stockholm, Sweden
5Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
6Department of Otorhinolaryngology - Head and Neck Surgery, Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022030121280
Language: English
Published: Informa, 2020
Publish Date: 2022-03-01
Description:

Abstract

Background and aims: Stage II cancer of the tongue is mostly managed surgically both locally and regionally. However, indications for postoperative radiotherapy and reconstructive options vary between centers. This paper aims to describe differences in treatment in a geographically homogenous cohort.

Methods: A retrospective comparison was made between two cohorts of clinical T2N0 tongue cancer from Finland and Sweden. The Finnish cohort included 75 patients and the Swedish 54. All patients had curative intent of treatment and no previous head and neck cancer. Data analyzed consisted of pathological stage, size and thickness of tumor, frequency of reconstruction, radiotherapy delivered, and survival.

Results: The Finnish cohort included a higher proportion of patients managed with reconstructive surgery (67%) than the Swedish cohort (0%), p <.00001. More patients were treated with postoperative radiotherapy (84%) in the Swedish cohort than in the Finnish (54%), p < .0002. The Finnish cohort had a higher level of survival and included more frequent downstaging (cTNM to pTNM).

Conclusions and significance: Our data indicate a major difference in the management of T2N0 oral tongue cancer. The optimal cut-off size and growth pattern of the tumor warranting reconstruction should be further evaluated in a prospective manner considering both survival and quality of life.

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Chinese abstract

背景与目的: II期舌癌多为局部或区域手术治疗。然而, 术后放射治疗和重建选择的标示因中心而异。本文旨在描述对地理上同质的患者群治疗上的差异。

方法: 回顾性比较芬兰和瑞典两组临床T2N0舌癌患者的临床资料。芬兰组包括75名患者, 瑞典组54名。所有患者均具有治疗目的, 无头颈部恶性肿瘤。所分析的数据包括病理分期、肿瘤大小和厚度、重建频率、放射治疗和生存率。

结果: 芬兰组中接受重建手术的患者比例(67%)高于瑞典组(0%), p %lt;0.00001。瑞典组中接受术后放射治疗的患者(84%)多于芬兰组(54%), p %lt;0.0002。芬兰组的生存率较高, 并包括更高频率的降阶(从cTNM到pTNM。

结论与意义: 我们的数据表明, 在治疗T2N0口腔舌癌方面存在重大差异。应以考虑生存率和生活质量这种前瞻性的方式进一步评估肿瘤最佳切除大小和生长模式, 以确保舌重建。

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Series: Acta oto-laryngologica
ISSN: 0001-6489
ISSN-E: 1651-2251
ISSN-L: 0001-6489
Volume: 140
Issue: 2
Pages: 188 - 194
DOI: 10.1080/00016489.2019.1699663
OADOI: https://oadoi.org/10.1080/00016489.2019.1699663
Type of Publication: A1 Journal article – refereed
Field of Science: 3125 Otorhinolaryngology, ophthalmology
3122 Cancers
Subjects:
Copyright information: © 2020 Acta Odontologica Scandinavica Society. This is an Accepted Manuscript of an article published by Taylor & Francis in Acta Odontologica Scandinavica on 18 Dec 2019, available online: http://doi.org/10.1080/00016489.2019.1699663.