University of Oulu

Satu K. Jyväkorpi, Annele Urtamo, Arto Y. Strandberg, Mikaela von Bonsdorff, Veikko Salomaa, Mika Kivimäki, Kari Luotola, Timo E. Strandberg, Associations of overweight and metabolic health with successful aging: 32-year follow-up of the Helsinki Businessmen Study, Clinical Nutrition, Volume 39, Issue 5, 2020, Pages 1491-1496, ISSN 0261-5614, https://doi.org/10.1016/j.clnu.2019.06.011

Associations of overweight and metabolic health with successful aging : 32-year follow-up of the Helsinki Businessmen Study

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Author: Jyväkorpi, Satu K.1; Urtamo, Annele1; Strandberg, Arto Y.1;
Organizations: 1University of Helsinki, Clinicum, and Helsinki University Hospital, Helsinki, Finland
2Folkhälsan Research Centre, Helsinki, Finland
3University of Jyväskylä, Faculty of Sport and Health Sciences, Jyväskylä, Finland
4THL-National Institute for Health and Welfare, Helsinki, Finland
5University College London, London, United Kingdom
6University of Oulu, Center for Life Course Health Research, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022030121322
Language: English
Published: Elsevier, 2020
Publish Date: 2022-03-01
Description:

Abstract

Background & aims: Prognostic significance of metabolically healthy overweight and obesity (MHO) is under debate. However the relationship between MHO and health-related quality of life (HRQoL) is less studied. We compared successful aging (longevity plus HRQoL) in men with MHO, metabolically healthy normal weight (MHN) and metabolically unhealthy overweight and obesity (MUO).

Methods: In the Helsinki Businessmen Study longitudinal cohort, consisting of men born 1919 to 1934. In 1985/86, overweight (BMI≥25 kg/m²) and metabolic health were determined in 1309 men (median age 60 years). HRQoL was assessed using RAND-36/SF-36 in 2000 and 2007, and all-cause mortality retrieved from registers up to 2018. The proportion of men reaching 90 years was also calculated.

Results: Of the men, 469 (35.8%), 538 (41.1%), 276 (21.1%), and 26 (2.0%) were MHN, MHO, MUO and MUN, respectively. During the 32-year follow-up, 72.3% men died. With MHN as reference, adjusted hazard ratio with all-cause mortality was 1.08 (95% confidence interval [CI] 0.93 to 1.27) for MHO, and 1.18 (95% CI 0.95 to 1.47) for MUO. During follow-up, 273 men reached 90 years. With MHN as reference, adjusted odds ratio for MHO was 0.82 (95% CI 0.59 to 1.14) and 0.62 (95% CI 0.41 to 0.95) for MUO. Men in MHN group scored generally highest in RAND-36 HRQoL subscales in 2000 and 2007, of those significantly better in Physical functioning, Role physical, Role emotional, Bodily Pain, and General health sub-scales compared to MHO group in 2000.

Conclusions: As compared to MHN, MHO in late midlife does not increase mortality, but impairs odds for successful aging.

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Series: Clinical nutrition
ISSN: 0261-5614
ISSN-E: 1532-1983
ISSN-L: 0261-5614
Volume: 39
Issue: 5
Pages: 1491 - 1496
DOI: 10.1016/j.clnu.2019.06.011
OADOI: https://oadoi.org/10.1016/j.clnu.2019.06.011
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: This work was supported by Gustaf och Victoria Frimurarestiftelse, Sweden; VTR-funding of the Helsinki University Hospital (TYH 2014245; 2015211), Finland; the Academy of Finland (grant number 311492). In addition, SKJ is supported by Päivikki Ja Sakari Sohlberg Foundation, Finland; MK is supported by NordForsk, the UK Medical Research Council (R024227), United Kingdom and Helsinki Institute of Life Sciences. Finland; VS is supported by the Finnish Foundation for Cardiovascular Research. The sponsors had no role in the design or conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Copyright information: © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license by http://creativecommons.org/licenses/by-nc-nd/4.0/.
  https://creativecommons.org/licenses/by-nc-nd/4.0/