University of Oulu

Ali Abou-Hassan, Alexandre Barros, Noor Buchholz, Dario Carugo, Francesco Clavica, Petra de Graaf, Julia de La Cruz, Wolfgang Kram, Filipe Mergulhao, Rui L Reis, Ilya Skovorodkin, Federico Soria, Seppo Vainio & Shaokai Zheng (2021) Potential strategies to prevent encrustations on urinary stents and catheters – thinking outside the box: a European network of multidisciplinary research to improve urinary stents (ENIUS) initiative, Expert Review of Medical Devices, 18:7, 697-705, DOI: 10.1080/17434440.2021.1939010

Potential strategies to prevent encrustations on urinary stents and catheters – thinking outside the box : a European network of multidisciplinary research to improve urinary stents (ENIUS) initiative

Saved in:
Author: Abou-Hassan, Ali1; Barros, Alexandre2; Buchholz, Noor3;
Organizations: 1Physico-chimie des Électrolytes Et Nanosystèmes Interfaciaux, Sorbonne Université, Paris, France
23B’s Research Group, University of Minho, BarcoGuimaraes, Portugal
3U-merge, Scientific Office, Athens, Greece
4Department of Pharmaceutics, School of Pharmacy, University College London, London, UK
5ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland
6Department of Urology, University Medical Center Utrecht, Utrecht, The Netherlands
7Jesus Uson Minimally Invasive Surgery Centre Foundation. Caceres, Spain
8Department Of Urology, University Medical Center Rostock, Germany
9LEPABE, Faculty of Engineering, University of Porto, Porto, Portugal
10Organogenesis Laboratory, Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
11Flagship GeneCellNano, Infotech Oulu - Kvantum Institut, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022030321760
Language: English
Published: Informa, 2021
Publish Date: 2022-06-11
Description:

Abstract

Introduction: Urinary stents have been around for the last 4 decades, urinary catheters even longer. They are associated with infections, encrustation, migration, and patient discomfort. Research efforts to improve them have shifted onto molecular and cellular levels. ENIUS brought together translational scientists to improve urinary implants and reduce morbidity.

Methods & materials: A working group within the ENIUS network was tasked with assessing future research lines for the improvement of urinary implants. Topics were researched systematically using Embase and PubMed databases. Clinicaltrials.gov was consulted for ongoing trials.

Areas covered: Relevant topics were coatings with antibodies, enzymes, biomimetics, bioactive nano-coats, antisense molecules, and engineered tissue. Further, pH sensors, biodegradable metals, bactericidal bacteriophages, nonpathogenic uropathogens, enhanced ureteric peristalsis, electrical charges, and ultrasound to prevent stent encrustations were addressed.

Expert opinion: All research lines addressed in this paper seem viable and promising. Some of them have been around for decades but are yet to proceed to clinical application (i.e. tissue engineering). Others are very recent and, at least in urology, still only conceptual (i.e. antisense molecules). Perhaps the most important learning point resulting from this pan-European multidisciplinary effort is that collaboration between all stakeholders is not only fruitful but also truly essential.

see all

Series: Expert review of medical devices
ISSN: 1743-4440
ISSN-E: 1745-2422
ISSN-L: 1743-4440
Volume: 18
Issue: 7
Pages: 697 - 705
DOI: 10.1080/17434440.2021.1939010
OADOI: https://oadoi.org/10.1080/17434440.2021.1939010
Type of Publication: A2 Review article in a scientific journal
Field of Science: 217 Medical engineering
3111 Biomedicine
3141 Health care science
318 Medical biotechnology
Subjects:
Funding: ENIUS (CA16217) is supported by the European Cooperation in Science and Technology (COST). It is a four-year project (COST action). COST is a funding organization by the European Union (EU) for the creation of research networks.
Copyright information: © 2021 Informa UK Limited, trading as Taylor & Francis Group. This is an Accepted Manuscript version of the following article, accepted for publication in International Journal of Design Creativity and Innovation. Ali Abou-Hassan, Alexandre Barros, Noor Buchholz, Dario Carugo, Francesco Clavica, Petra de Graaf, Julia de La Cruz, Wolfgang Kram, Filipe Mergulhao, Rui L Reis, Ilya Skovorodkin, Federico Soria, Seppo Vainio & Shaokai Zheng (2021) Potential strategies to prevent encrustations on urinary stents and catheters – thinking outside the box: a European network of multidisciplinary research to improve urinary stents (ENIUS) initiative, Expert Review of Medical Devices, 18:7, 697-705, DOI: 10.1080/17434440.2021.1939010. It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
  https://creativecommons.org/licenses/by-nc/4.0/