Laatikainen, O., Sneck, S. & Turpeinen, M. Medication-related adverse events in health care—what have we learned? A narrative overview of the current knowledge. Eur J Clin Pharmacol 78, 159–170 (2022). https://doi.org/10.1007/s00228-021-03213-x
Medication-related adverse events in health care—what have we learned? : a narrative overview of the current knowledge
|Author:||Laatikainen, O.1,2; Sneck, S.3; Turpeinen, M.1,2,3|
1Research Unit of Biomedicine and Medical Research Center Oulu, Oulu, Finland
2Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland
3Oulu University Hospital, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 1.2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2022030822358
|Publish Date:|| 2022-03-08
Purpose: Although medication-related adverse events (MRAEs) in health care are vastly studied, high heterogeneity in study results complicates the interpretations of the current situation. The main objective of this study was to form an up-to-date overview of the current knowledge of the prevalence, risk factors, and surveillance of MRAEs in health care.
Methods: Electronic databases (PubMed, MEDLINE, Web of Science, and Scopus) were searched with applicable search terms to collect information on medication-related adverse events. In order to obtain an up-to-date view of MRAEs, only studies published after 2000 were accepted.
Results: The prevalence rates of different MRAEs vary greatly between individual studies and meta-analyses. Study setting, patient population, and detection methods play an important role in determining detection rates, which should be regarded while interpreting the results. Medication-related adverse events are more common in elderly patients and patients with lowered liver or kidney function, polypharmacy, and a large number of additional comorbidities. However, the risk of MRAEs is also significantly increased by the use of high-risk medicines but also in certain care situations. Preventing MRAEs is important as it will decrease patient mortality and morbidity but also reduce costs and functional challenges related to them.
Conclusions: Medication-related adverse events are highly common and have both immediate and long-term effects to patients and healthcare systems worldwide. Conclusive solutions for prevention of all medication-related harm are impossible to create. In the future, however, the development of efficient real-time detection methods can provide significant improvements for event prevention and forecasting.
European journal of clinical pharmacology
|Pages:||159 - 170|
|Type of Publication:||
A2 Review article in a scientific journal
|Field of Science:||
Open access funding provided by University of Oulu including Oulu University Hospital.
© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.