Kandurova, K.Y., Potapova, E.V., Zherebtsov, E.A. et al. Testing a Fine-Needle Optical Probe for Recording Changes in the Fluorescence of Coenzymes of Cellular Respiration. Opt. Spectrosc. 128, 742–751 (2020). https://doi.org/10.1134/S0030400X20060089
Testing a fine-needle optical probe for recording changes in the fluorescence of coenzymes of cellular respiration
|Author:||Kandurova, K. Yu.1; Potapova, E. V.1; Zherebtsov, E. A.1,2;|
1Research and Development Center of Biomedical Photonics, Orel State University, 302026, Orel, Russia
2University of Oulu, Optoelectronics and Measurement Techniques Unit, 90570, Oulu, Finland
3Department of Industrial Chemistry and Biotechnology, Orel State University, 302026, Orel, Russia
4Orel Regional Clinical Hospital, 302028, Orel, Russia
5Problem Research Laboratory “Diagnostic Researches and Mini-invasive Technologies,” Smolensk State Medical University, 214006, Smolensk, Russia
6Federal Scientific and Clinical Center for Specialized Medical Service and Medical Technologies, Federal Biomedical Agency of Russia, 115682, Moscow, Russia
7Central Research Institute of Tuberculosis, 107564, Moscow, Russia
|Online Access:||PDF Full Text (PDF, 1.4 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2022031022943
|Publish Date:|| 2022-03-10
A device for optical biopsy with a fluorescence spectroscopy channel and a fine-needle optical probe for use in fine-needle aspiration biopsy of liver tumors is described. To test the developed device, experimental measurements of the fluorescence of internal organs of a laboratory rat were carried out in vivo while exposing the tissue surface to mitochondrial uncoupling to induce changes in cell respiration. The results of the model experiment showed the ability of the developed channel to detect changes in fluorescence due to changes in the processes of oxidative phosphorylation of mitochondria.
Optics and spectroscopy
|Pages:||742 - 751|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
213 Electronic, automation and communications engineering, electronics
This work was supported by the Russian Science Foundation, project no. 18-15-00201.
© The Author(s), 2020, published in Optika i Spektroskopiya. This is a post-peer-review, pre-copyedit version of an article published in Optics and Spectroscopy.
The final authenticated version is available online at: http://dx.doi.org/10.1134/S0030400X20060089.