University of Oulu

Petri Kresanov, Juha Mykkänen, Markku Ahotupa, Mika Ala-Korpela, Markus Juonala, Jari Kaikkonen, Mika Kähönen, Terho Lehtimäki, Tommi Vasankari, Jorma Viikari, Olli T. Raitakari, The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions. The Cardiovascular Risk in Young Finns Study, Free Radical Biology and Medicine, Volume 162, 2021, Pages 225-232, ISSN 0891-5849, https://doi.org/10.1016/j.freeradbiomed.2020.10.020

The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions : the Cardiovascular Risk in Young Finns Study

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Author: Kresanov, Petri1,2; Mykkänen, Juha1,2; Ahotupa, Markku1;
Organizations: 1From Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
2Centre for Population Health Research, University of Turku and Turku University Hospital, Finland
3Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland
4NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
5Department of Internal Medicine, University of Turku, Finland
6Division of Medicine, Turku University Hospital, Finland
7Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
8Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Finland
9Department of Clinical Chemistry, Fimlab Laboratories, And Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland
10The UKK Institute for Health Promotion Research, Tampere, Finland
11The National Institute for Health and Welfare, Helsinki, Finland
12Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
13Departments of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022031523481
Language: English
Published: Elsevier, 2021
Publish Date: 2022-03-15
Description:

Abstract

Objective: Oxidation of low-density lipoprotein (LDL) may promote atherosclerosis, whereas the reverse transport of oxidized lipids by high-density lipoprotein (HDL) may contribute to atheroprotection. To provide insights into the associations of lipoprotein lipid oxidation markers with lipoprotein subclasses at the population level, we investigated the associations of oxidized HDL lipids (oxHDLlipids) and oxidized LDL lipids (oxLDLlipids) with lipoprotein subclasses in a population-based cross-sectional study of 1395 Finnish adults ages 24–39 years.

Methods: The analysis of oxidized lipids was based on the determination of the baseline level of conjugated dienes in lipoprotein lipids. A high-throughput nuclear magnetic resonance (NMR) platform was used to quantify circulating lipoprotein subclass concentrations and analyze their lipid compositions.

Results: OxHDLlipids were mainly not associated with lipoprotein subclass lipid concentrations and lipid composition after adjustment for Apolipoprotein-A1 (Apo-A1), waist circumference and age. OxLDLlipids were associated with several markers of lipoprotein subclass lipid concentrations and composition after adjustment for Apolipoprotein-B (Apo-B), age and waist circumference. Several measures of HDL and LDL subclasses, including phospholipid and triglyceride composition, associated directly with oxLDLlipids. Cholesterol ester and free cholesterol composition in HDL and LDL associated inversely with oxLDLlipids.

Conclusions: We conclude that these results do not support the idea that HDL’s particle size or composition would reflect its functional capacity in the reverse transport of oxidized lipids. On the contrary, oxLDLlipids were associated with the entire lipoprotein subclass profile, including numerous associations with the compositional descriptors of the particles. This is in line with the suggested role of LDL oxidation in atherogenesis.

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Series: Free radical biology & medicine
ISSN: 0891-5849
ISSN-E: 1873-4596
ISSN-L: 0891-5849
Volume: 162
Pages: 225 - 232
DOI: 10.1016/j.freeradbiomed.2020.10.020
OADOI: https://oadoi.org/10.1016/j.freeradbiomed.2020.10.020
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Subjects:
HDL
LDL
Funding: The Young Finns Study has been financially supported by the Academy of Finland: grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); European Research Council (grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation; and The Paulo Foundation. MAK is holding a research grant from the Sigrid Juselius Foundation, Finland.
Copyright information: © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license by http://creativecommons.org/licenses/by-nc-nd/4.0/.
  https://creativecommons.org/licenses/by-nc-nd/4.0/