University of Oulu

Rajula, H.S.R., Manchia, M., Agarwal, K. et al. Overview of CAPICE—Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe—an EU Marie Skłodowska-Curie International Training Network. Eur Child Adolesc Psychiatry 31, 829–839 (2022).

Overview of CAPICE—childhood and adolescence psychopathology : unravelling the complex etiology by a large interdisciplinary collaboration in Europe—an EU Marie Skłodowska‑Curie International Training Network

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Author: Rajula, Hema Sekhar Reddy1; Manchia, Mirko2,3; Agarwal, Kratika4;
Organizations: 1Neonatal Intensive Care Unit, Department of Surgical Sciences, AOU and University of Cagliari, Cagliari, Italy
2Section of Psychiatry, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy
3Department of Pharmacology, Dalhousie University, Halifax, NS, Canada
4Department of Learning, Data Analytics and Technology, University of Twente, Enschede, The Netherlands
5Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
6Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
7Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
8Child and Adolescent Psychiatry, Erasmus University Medical Centre, Rotterdam, The Netherlands
9Centre for Ethics, Law and Mental Health (CELAM), Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden
10MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
11School of Psychological Science, University of Bristol, Bristol, UK
12Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
13Janssen Pharmaceutical, Global Commercial Strategy Organization, Stockholm, Sweden
14Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
15Child and Youth Mental Health Service, Children’s Health Queensland Hospital and Health Service, Brisbane, Australia
16Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulun yliopisto, Oulu, Finland
17Biocenter Oulu, University of Oulu, Oulu, Finland
18Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland
19Department of Life Sciences, College of Health and Life Sciences, Brunel University, London, UK
20University of Cagliari, Cagliari, Italy
21PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway
22Norwegian Institute of Public Health, Oslo, Norway
23Department of Pharmacy, University of Oslo, Oslo, Norway
24Child Health Research Centre, Level 6, Centre for Children’s Health Research, University of Queensland, 62 Graham Street, South Brisbane, QLD, 4101, Australia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
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Language: English
Published: Springer Nature, 2021
Publish Date: 2022-03-28


The Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER) identified child and adolescent mental illness as a priority area for research. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) is a European Union (EU) funded training network aimed at investigating the causes of individual differences in common childhood and adolescent psychopathology, especially depression, anxiety, and attention deficit hyperactivity disorder. CAPICE brings together eight birth and childhood cohorts as well as other cohorts from the EArly Genetics and Life course Epidemiology (EAGLE) consortium, including twin cohorts, with unique longitudinal data on environmental exposures and mental health problems, and genetic data on participants. Here we describe the objectives, summarize the methodological approaches and initial results, and present the dissemination strategy of the CAPICE network. Besides identifying genetic and epigenetic variants associated with these phenotypes, analyses have been performed to shed light on the role of genetic factors and the interplay with the environment in influencing the persistence of symptoms across the lifespan. Data harmonization and building an advanced data catalogue are also part of the work plan. Findings will be disseminated to non-academic parties, in close collaboration with the Global Alliance of Mental Illness Advocacy Networks-Europe (GAMIAN-Europe).

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Series: European child & adolescent psychiatry
ISSN: 1018-8827
ISSN-E: 1435-165X
ISSN-L: 1018-8827
Volume: 31
Issue: 5
Pages: 829 - 839
DOI: 10.1007/s00787-020-01713-2
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Funding: This work has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie CAPICE Project grant agreement number 721567 CAPICE
Copyright information: © The Author(s) 2021.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit