University of Oulu

Aulikki Kononoff, Pia Elfving, Pirkko Pussinen, Sohvi Hörkkö, Hannu Kautiainen, Leena Arstila, Leena Laasonen, Elina Savolainen, Helena Niinisalo, Jarno Rutanen, Olga Marjoniemi, Mari Hämäläinen, Katriina Vuolteenaho, Eeva Moilanen & Oili Kaipiainen-Seppänen (2020) Association of rheumatoid arthritis disease activity and antibodies to periodontal bacteria with serum lipoprotein profile in drug naive patients, Annals of Medicine, 52:1-2, 32-42, DOI: 10.1080/07853890.2020.1724321

Association of rheumatoid arthritis disease activity and antibodies to periodontal bacteria with serum lipoprotein profile in drug naive patients

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Author: Kononoff, Aulikki1; Elfving, Pia1; Pussinen, Pirkko2;
Organizations: 1Department of Medicine, Kuopio University Hospital, Kuopio, Finland
2Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
3Institute of Diagnostics, Medical Microbiology and Immunology, Research Unit of Biomedicine, Oulu University Hospital, University of Oulu and Medical Research Center and Nordlab Oulu, Oulu, Finland
4Unit of Primary Health Care, Kuopio University Hospital, Kuopio, Finland
5Unit of Family Practice, Central Finland Central Hospital, Jyväskylä, Finland
6Department of Medicine, Iisalmi Hospital
7Helsinki Medical Imaging Center, Helsinki University Hospital, Helsinki, Finland
8Department of Medicine, Varkaus Hospital
9Outpatient Clinic, Suonenjoki Health Center
10School of Medicine, The Immunopharmacology Research Group, Tampere University Hospital, University of Tampere, Tampere, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
Persistent link:
Language: English
Published: Informa, 2020
Publish Date: 2022-04-07


Objective: We investigated lipid concentrations, particle sizes and antibodies binding to periodontal bacteria Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis and to malondialdehyde-acetaldehyde (MAA) modified low-density lipoprotein in immunoglobulin (Ig) class A, G and M among patients with newly diagnosed rheumatoid arthritis (RA) in a population-based cohort.

Methods: Concentrations and sizes of lipoprotein particles analysed by proton nuclear magnetic resonance spectroscopy and antibody levels to MAA modified low-density lipoprotein were studied at baseline and after one-year of follow-up. Serum Ig A and G class antibodies to periodontal bacteria were determined at baseline.

Results: Sixty-three patients were divided into tertiles according to disease activity by disease activity score with 28 joint count and erythrocyte sedimentation rate (ESR) (<3.9, 3.9–4.7, >4.7). Small low-density lipoprotein concentration was lowest in the tertile with the highest disease activity. In high-density lipoprotein, the concentrations of total, medium and small particles decreased with disease activity. The particle size in low-density lipoprotein associated with disease activity and the presence of antibodies to P. gingivalis. Ig G and M antibodies to MAA modified low-density lipoprotein correlated with disease activity. Inflammation associated changes faded by one year.

Conclusions: Drug naive RA patients had proatherogenic changes in lipid profiles, but they were reversible, when inflammation diminished.

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Series: Annals of medicine
ISSN: 0785-3890
ISSN-E: 1365-2060
ISSN-L: 0785-3890
Volume: 52
Issue: 1-2
Pages: 32 - 42
DOI: 10.1080/07853890.2020.1724321
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: This study was supported by a grant from Rheumatism Research Foundation, Finnish Rheumatism Association, Finnish Cultural Foundation, Northern Savo Regional fund, and the Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding (AK, OK-S) and Sigrid Juselius Foundation and Finnish Foundation for Cardiovascular Research (SH). The Competitive Research Funding of the Tampere University Hospital (KV,EM), Scandinavian Rheumatology Research Foundation (KV), Maire Lisko Foundation (KV), the Paolo Foundation (EM) and the Academy of Finland (EM).
Copyright information: © 2020 Informa UK Limited, trading as Taylor & Francis Group. This is an Accepted Manuscript of an article published by Taylor & Francis in Annals of Medicine on 10 Feb 2020, available online: