University of Oulu

RSC Adv., 2022,12, 1479-1485,

Hyperpolarised NMR to aid molecular profiling of electronic cigarette aerosols

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Author: Tickner, Ben. J.1; Komulainen, Sanna1; Palosaari, Sanna2,3;
Organizations: 1NMR Research Unit, Faculty of Science, University of Oulu, Finland
2Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Finland
3Medical Research Center Oulu, Faculty of Medicine, University of Oulu and Oulu University Hospital, Finland
4Division of Orthopedic Surgery, Oulu University Hospital, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
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Language: English
Published: Royal Society of Chemistry, 2022
Publish Date: 2022-04-11


Signal amplification by reversible exchange (SABRE) hyperpolarisation is used to enhance the NMR signals of nicotine and acrolein in methanol-d₄ solutions of electronic cigarette aerosols. Consequently, detection of 74 μM nicotine is possible in just a single scan ¹H NMR spectrum. The first example of an aldehyde hyperpolarised using SABRE is demonstrated and we work towards novel real-world applications of SABRE-hyperpolarised NMR for chemical analysis.

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Series: RSC advances
ISSN: 2046-2069
ISSN-E: 2046-2069
ISSN-L: 2046-2069
Volume: 12
Pages: 1479 - 1485
DOI: 10.1039/D1RA07376A
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
116 Chemical sciences
Funding: Financial support from the European Research Council (Project number 772110), Academy of Finland (grant no. 323480 and 340099) and the University of Oulu (Kvantum Institute) is gratefully acknowledged.
Academy of Finland Grant Number: 323480
Detailed Information: 323480 (Academy of Finland Funding decision)
340099 (Academy of Finland Funding decision)
Copyright information: © 2021 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.