University of Oulu

Xu, S., Hansen, S., Rautio, A., Järvelin, M.-R., Abass, K., Rysä, J., Palaniswamy, S., Huber, S., Grimalt, J. O., Dumas, P., & Odland, J. Ø. (2022). Monitoring temporal trends of dioxins, organochlorine pesticides and chlorinated paraffins in pooled serum samples collected from Northern Norwegian women: The MISA cohort study. Environmental Research, 204, 111980. https://doi.org/10.1016/j.envres.2021.111980

Monitoring temporal trends of dioxins, organochlorine pesticides and chlorinated paraffins in pooled serum samples collected from Northern Norwegian women : the MISA cohort study

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Author: Xu, Shanshan1; Hansen, Solrunn2; Rautio, Arja3,4;
Organizations: 1Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, 7491, Norway
2Department of Health and Care Sciences, UiT the Arctic University of Norway, Tromsø, 9037, Norway
3Arctic Health, Faculty of Medicine, University of Oulu, Oulu, Finland
4Thule Institute, University of Arctic, University of Oulu, Oulu, Finland
5Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
6Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
7Unit of Primary Care, Oulu University Hospital, Oulu, Finland
8MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom
9Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, United Kingdom
10Department of Pesticides, Menoufia University, Menoufia, Egypt
11Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
12Department of Laboratory Medicine, University Hospital of North Norway, Sykehusveien 38, Tromsø, NO-9038, Norway
13Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18, Barcelona, Catalonia, 08034, Spain
14Institut Nacional de Santé Publique du Québec (INSPQ), Québec City, Canada
15Department of General Hygiene I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119992, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022041328593
Language: English
Published: Elsevier, 2022
Publish Date: 2022-08-04
Description:

Abstract

The ubiquitous presence of legacy and emerging persistent organic pollutants (POPs) in the environmental matrices poses a potential hazard to the humans and creating public health concerns. The present study aimed to evaluate dioxins, dioxin-like polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and chlorinated paraffins (CPs) concentrations in serum of women (postpartum, pregnant and non-pregnant) from Northern Norway to better understand their exposure and contamination status as well as temporal trends across 2007–2009 (MISA 1) to 2019 (MISA 2). Sixty-two blood samples from the MISA 1 cohort and 38 samples from MISA 2 were randomly selected in this study (n = 100). Ninety samples from postpartum (MISA 1) and pregnant women (MISA 2) were randomly combined into 9 pools, with 9–11 individual samples contributing to each pool keeping the groups of pregnant and postpartum women. Remaining 10 samples from non-pregnant women (MISA 2) were allocated into separate group. Geometric mean, minimum and maximum were used to describe the serum concentrations of pooled POPs in MISA cohort. Mann-Whitney U test and independent sample t-test were applied for trend analysis of blood levels of POPs between MISA 1 and MISA 2. We found the serum concentrations of selected POPs in this study to be at lower range. Serum concentrations of dibenzo-p-dioxins (PCDDs) (p = 0.010), polychlorinated dibenzofurans (PCDFs) (p = 0.002), dioxins-like PCBs (p = 0.001), hexachlorobenzene (HCB) (p < 0.001) and p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE) (p = 0.002) were decreased between the studied time. In contrast, the serum concentrations of medium chain chlorinated paraffins showed an increasing trend between 2007 and 2009 and 2019 (p = 0.019). Our findings report a particular concern of emerging contaminant medium chain chlorinated paraffin exposure to humans. Future observational studies with repeated measurements of chlorinated paraffins in general populations worldwide and large sample size are warranted.

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Series: Environmental research
ISSN: 0013-9351
ISSN-E: 1096-0953
ISSN-L: 0013-9351
Volume: 204
Article number: 111980
DOI: 10.1016/j.envres.2021.111980
OADOI: https://oadoi.org/10.1016/j.envres.2021.111980
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Subjects:
Funding: This paper was supported by funding from the European Union’s Horizon 2020 program project EDCMET (No. 825762) and the Norwegian Environment Agency, Norway project (No. 19087505). Financial support for chloroparaffines method development was provided by the Fram Centre Flagship Program “Hazardous substances –effects on ecosystems and human health” (Project 481/762019:Screening for Emerging Arctic health Risks to Circumpolar Human populations (SEARCH)).
EU Grant Number: (825762) EDCMET - Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways
Copyright information: © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
  https://creativecommons.org/licenses/by/4.0/