University of Oulu

Jaekel, J., Anderson, P.J., Bartmann, P., Cheong, J.L.Y., Doyle, L.W., Hack, M., Johnson, S., Marlow, N., Saigal, S., Schmidt, L., Sullivan, M.C. and Wolke, D. (2022), Mathematical performance in childhood and early adult outcomes after very preterm birth: an individual participant data meta-analysis. Dev Med Child Neurol, 64: 421-428.

Mathematical performance in childhood and early adult outcomes after very preterm birth : an individual participant data meta-analysis

Saved in:
Author: Jäkel, Julia1,2,3,4; Anderson, Peter J5,6; Bartmann, Peter7;
Organizations: 1Psychology, University of Oulu, Oulu, Finland
2Psychology, University of Warwick, Coventry, UK
3Child and Family Studies/Psychology, University of Tennessee Knoxville, Knoxville, TN, USA
4Department of Health Sciences, University of Leicester, Leicester, UK
5Turner Institute for Brain & Mental Health, School of Psychology Sciences, Monash University, Melbourne, VIC, Australia
6Clinical Sciences, Murdoch Children's Research Institute, Melbourne, VIC, Australia
7Children's Hospital, University Hospital Bonn, Bonn, Germany
8Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia
9Neonatal Services, Royal Women’s Hospital, Melbourne, VIC, Australia
10Neonatology, Case Western Reserve University School of Medicine, Cleveland, OH, USA
11EGA Institute for Women's Health, University College London, London, UK
12Pediatrics, McMaster University, Hamilton, ON, USA
13Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada
14College of Nursing, University of Rhode Island, Providence, RI, USA
15Warwick Medical School, University of Warwick, Coventry, UK
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
Persistent link:
Language: English
Published: John Wiley & Sons, 2022
Publish Date: 2022-06-20


Aim: To investigate the strength of the independent associations of mathematics performance in children born very preterm (<32wks’ gestation or <1500g birthweight) with attending postsecondary education and their current employment status in young adulthood.

Method: We harmonized data from six very preterm birth cohorts from five different countries and carried out one-stage individual participant data meta-analyses (n=954, 52% female) using mixed effects logistic regression models. Mathematics scores at 8 to 11 years of age were z-standardized using contemporary cohort-specific controls. Outcomes included any postsecondary education, and employment/education status in young adulthood. All modelswere adjusted for year of birth, gestational age, sex, maternal education, and IQ in childhood.

Results: Higher mathematics performance in childhood was independently associated with having attended any postsecondary education (odds ratio [OR] per SD increase in mathematics z-score: 1.36 [95% confidence interval {CI}: 1.03, 1.79]) but not with current employment/education status (OR 1.14 per SD increase [95% CI: 0.87, 1.48]).

Interpretation: Among populations born very preterm, childhood mathematics performance is important for adult educational attainment, but not for employment status.

see all

Series: Developmental medicine & child neurology
ISSN: 0012-1622
ISSN-E: 1469-8749
ISSN-L: 0012-1622
Volume: 64
Issue: 4
Pages: 421 - 428
DOI: 10.1111/dmcn.15132
Type of Publication: A1 Journal article – refereed
Field of Science: 515 Psychology
Funding: JJ was supported by grant JA 1913/2-2 from the German Research Foundation. DW and PB were supported by an EU Horizon 2020 grant 733280 (RECAP-preterm) and DW by the New Opportunities for Research Funding Agency Co-operation in Europe, Dynamics of Inequality Across the Life-course Program (grant number: 462-16-040). The EPICure studies were funded by the Medical Research Council (MR/N024869/1). NM receives funding from the NIHR Biomedical Research Centre at University College London/University College London Hospitals. The McMaster Study was supported by grant No. ESPM85-201, Hospital for Sick Children Foundation, Toronto, Ontario and a Team Grant (2009H00529) from the Canadian Institutes of Health Research awarded to LS and SS. The Rhode Island cohort studies were funded by the National Institutes of Health, National Institute of Nursing Research (Grant # R01 NR 003695-01; R01 NR003695-14). PA was supported by the Australian National Health and Medical Research Council Investigator Grant (#1176077). JC was supported by Australian Medical Research Future Fund Career Development Fellowship (#1141354). The Victorian Infant Collaborative Study studies were funded by the Australian NHMRC (#1104300, #491246).
Copyright information: © 2021 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.