University of Oulu

Protsenko, M., Kerkelä, M., Miettunen, J., Auvinen, J., Järvelin, M.-R., Jones, P. B., Gissler, M., & Veijola, J. (2022). Cardiometabolic disorders in the offspring of parents with severe mental illness. Psychosomatic Medicine, 84(1), 2–9.

Cardiometabolic disorders in the offspring of parents with severe mental illness

Saved in:
Author: Protsenko, Maria1; Kerkelä, Martta1; Miettunen, Jouko2,3;
Organizations: 1Department of Psychiatry, University of Oulu
2Research Unit of Clinical Neuroscience, and Center for Life Course Health Research, University of Oulu
3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu
4Department of Psychiatry, University of Cambridge, Cambridge, England, United Kingdom
5THL, Information Services Department, Finnish Institute for Health and Welfare, Helsinki
6University of Turku, Research Centre for Child Psychiatry, Turku, Finland
7Department of Neurobiology, Care Sciences and Society, , Karolinska Institute, Stockholm, Sweden
8Department of Psychiatry, University Hospital of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link:
Language: English
Published: Wolters Kluwer, 2022
Publish Date: 2022-06-17


Objective: The elevated prevalence of cardiometabolic disorders is consistently reported in patients with severe mental illness (SMI). We explored the association between parental SMI and offspring cardiometabolic morbidity. Our hypothesis was that offspring of people with SMI have increased morbidity risk.

Method: The Northern Finland Birth Cohort 1966 is a study of offspring whose date of birth was expected in 1966. The follow-up lasted until 2015 (49 years). The final study sample included 11,175 children. We used parental SMI as the exposure in the study. The following cardiometabolic disorders were used as outcome measures: diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, obesity, and cerebrovascular disorders.

Results: There were 139 (14.7%; hazard ratios [HR] = 1.63; 95% confidence interval [CI] = 1.36–1.94) children of parents with SMI who developed cardiometabolic disorder during follow-up and 957 (9.4%) in the comparison cohort. Statistically significant HRs were found in males (HR = 1.95; 95% CI =1.56–2.44), but not in females (HR = 1.29; 95% CI = 0.96–1.73).

Conclusions: Having a cardiometabolic disorder was associated with male offspring of parents with SMI. Our findings suggest that there is an elevated risk of coronary artery disease, hyperlipidemia, obesity, and hypertension in the male offspring of parents with SMI. Our results suggest that the somatic health of offspring of parents with SMI should also be considered in addition to their mental health in clinical practice.

see all

Series: Psychosomatic medicine
ISSN: 0033-3174
ISSN-E: 1534-7796
ISSN-L: 0033-3174
Volume: 84
Issue: 1
Pages: 2 - 9
DOI: 10.1097/PSY.0000000000001022
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Funding: The Northern Finland Birth Cohort 1966 received financial support from University of Oulu Grant No. 24000692, Oulu University Hospital Grant No. 24301140, and ERDF European Regional Development Fund Grant No. 539/2010 A31592.
Copyright information: © 2021 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.