University of Oulu
Oulu University Library
OuluCRIS
Laturi
Muuntaja

Similar Items

Cover Image

Attina Ervaala, Hannele Laivuori, Mika Gissler, Juha Kere, Katja Kivinen, Anneli Pouta, Eero Kajantie, Seppo Heinonen, Satu Wedenoja, Characteristics of preeclampsia in donor cell gestations, Pregnancy Hypertension, Volume 27, 2022, Pages 59-61, ISSN 2210-7789, https://doi.org/10.1016/j.preghy.2021.12.005

Characteristics of preeclampsia in donor cell gestations

Saved in:
Author: Ervaala, Attina1; Laivuori, Hannele2,3,4; Gissler, Mika5,6;
Organizations: 1Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland
2Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, 33520 Tampere, Finland
3Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, 00290 Helsinki, Finland
4Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland
5Information Services Department, Finnish Institute for Health and Welfare, Helsinki, Finland
6Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
7Stem Cells and Metabolism Research Program, University of Helsinki, and Folkhälsan Research Center, 00290 Helsinki, Finland
8Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden
9Information Services Department, Finnish Institute for Health and Welfare, 00300 Helsinki, Finland
10PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, 90570 Oulu, Finland
11Public Health Promotion Unit, Finnish Institute for Health and Welfare, 00300 Helsinki and 90220 Oulu, Finland
12Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
13Children's Hospital, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2022042530188
Language: English
Published: Elsevier, 2022
Publish Date: 2022-04-25
Description:

Abstract

Pregnancies conceived through donor oocytes or sperm show increased risk for preeclampsia. We studied this issue in a preeclampsia case-control cohort (n = 2778), and found overrepresentation of donor cell gestations among women with preeclampsia (14/1627, 0.86%; OR 1.81; 95% CI: 1.07–3.08; P = 0.025) compared to the population data. Moreover, we observed excess of male births from donor cell pregnancies (male-to-female ratio 2.5 vs. 0.97; OR 2.57; 95% CI 1.02–6.36; P = 0.043). Maternal age (36.7 vs. 30.2; P < 0.0001) and preterm deliveries (64% vs. 38%; P = 0.046) distinguished donor cell gestations from other pregnancies with preeclampsia. These results support foreign fetal antigens as modulators of preeclampsia.

see all
Series: Pregnancy hypertension
ISSN: 2210-7789
ISSN-E: 2210-7797
ISSN-L: 2210-7789
Volume: 27
Pages: 59 - 61
DOI: 10.1016/j.preghy.2021.12.005
OADOI: https://oadoi.org/10.1016/j.preghy.2021.12.005
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
In vitro fertilization
Ovum donation
Preeclampsia
Pregnancy
Sperm donation
Article
Funding: This study was supported by: Academy of Finland (grants 121196, 134957, and 278941) (HL), Center for Innovative Medicine (CIMED, Sweden) (JK), Emil Aaltonen Foundation (EK), Finnish Foundation for Pediatric Research (EK), Finnish Medical Foundation (HL, SW), Finska Läkaresällskapet (HL), Föreningen Liv och Hälsa (JK), Jane and Aatos Erkko Foundation (JK, HL), Novo Nordisk Foundation (EK), Päivikki and Sakari Sohlberg Foundation (HL, SW), Research Funds of the University of Helsinki (HL), Sigrid Jusélius Foundation (EK, JK), Swedish Research Council (JK), and the Competitive State Research Financing of the Expert Responsibility area of Helsinki University Hospital (TYH2018305) (SH). The funders had no role in study design, data collection, data analysis, interpretation, or writing of the report.
Copyright information: © 2021 The Authors. Published by Elsevier B.V. on behalf of International Society for the Study of Hypertension in Pregnancy. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/